A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells

Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells

“…Measurement of MMP was performed by previously published method (Yee et al, 2007). Alterations in MMP were determined by staining the cells (5 × 10 5) with the indicator dye, JC-1.…”

Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1

“…HS-1200 {N-[(3a,5b,7a)-3,7-dihydroxy-24-oxocholan-24-yl] b-alanine benzyl ester}, a synthetic CDCA derivative, has shown anticancer activity in several human cancers. For instance, HS-1200 was shown to sensitize breast cancer MCF-7 cell to radiation-induced apoptosis [ 8 ]. Further, HS-1200 was shown to inhibit proliferation and promote apoptosis of both prostate cancer cells [ 9 ] and bone sarcoma cells [ 10 ].…”

Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines

“…By analogy to these natural compounds, some authors have synthesized several bile acid derivatives, which are conjugates of bile acids with amino acids. These compounds have shown antitumor effects in human cancer cells such as stomach cancer cells [7], glioblastoma multiforme [8], colon cancer [9], breast carcinoma [10], leukemic T cells [11], prostate cancer cells [12], cervical carcinoma [13], hepatocellular carcinoma [14,15] and breast cancer cells [16]. Only a few conjugate bile acids with amino acids are synthesized but their biological activities have been widely studied.…”