Abstract:21Background 22 The arsenal in anthelminthic treatment against schistosomiasis is limited and relies almost 23 exclusively on a single drug, praziquantel (PZQ). Thus, resistance to PZQ could constitute a 24 major threat. Even though PZQ is potent in killing adult worms, it has been shown to be limited 25 in its activity against earlier developmental stages. Current in vitro screening strategies for new 26 drugs depend on newly transformed schistosomulae (NTS) for initial hit identification, thereby 27 li… Show more
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