A novel cationic waterborne polyurethane coating modified by chitosan biguanide hydrochloride with application potential in medical catheters

Abstract

This study reported the synthesis and properties of a new cationic waterborne polyurethane coating. In this work, a chitosan derivative, chitosan biguanide hydrochloride (CSGH), was synthesized, which was used as a blocking agent and cross‐linking agent to participate in the copolymerization of waterborne polyurethane (WPU) and a bioactive ingredient to enhance the biocompatibility of the coating. FTIR results demonstrated the reaction of CSGH with WPU. Moreover, the particle size distribution of the emulsion and SEM results showed that CSGH and WPU were well integrated. Benefiting from the formation of the cross‐linking network, the thermodynamic properties of the coating were significantly improved. Furthermore, due to adding 3 wt% CSGH, the water contact angle of the coating surface decreased from 97.01° to 69.30°, indicating that the coating surface changed from hydrophobic to hydrophilic. And a specific resistance to Staphylococcus aureus and Escherichia coli was exhibited without cytotoxicity, the resistance rates could reach 85% and 91% respectively. It is highlighted that this WPU‐CSGH coating has great application potential in the field of medical interventional catheters.

Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(iii) metallodrugs

“…Polyurethanes have gained interest in different biomedical applications, from stents 10 or catheter implants 11 to “polymeric director” groups 12 and nanocapsules, 13 since they exhibit reasonable toxicity and biocompatibility, together with accessible and feasible synthetic procedures. Polyurethane–polyurea hybrid nanocapsules (NCs) have been previously reported by some of the authors as promising tools for different nanomedical solutions, 14 for example, in the fields of immunotherapy 15 and regenerative medicine.…”

Current Advances and Future Perspectives of Advanced Polymer Processing for Bone and Tissue Engineering: Morphological Control and Applications

“…Medical catheters are the most important application direction of polymer tubes ( Geyer et al, 2019 ), mainly including surgical catheters ( Hu et al, 2018 ), treatment and nursing catheters ( Neoh et al, 2017 ), and interventional medical catheters ( Liu et al, 2021 ). Interventional therapy is a newly developed medical technology, where catheters and other interventional medical devices can enter the human body to reach the target lesion location and to achieve precise and efficient treatment effects ( Jung et al, 2020 ; Hwang et al, 2022 ).…”

Dual‐drug delivery of sodium ceftriaxone and metronidazole by applying salt‐assisted chitosan nanoparticles: Stability, drug release, and time‐kill assay study against Bacteroides fragilis

“…It is the only biodegradable polymer with cationic characteristics. [25][26][27] This unique cationic property is due to the presence of the amino group in the body of chitosan polymer, which causes different properties in drug delivery systems. On the other hand, the biodegradability of chitosan has been confirmed by other authors.…”

“…Chitosan with a high deacetylation degree (85%–95%) applies for medical goals. It is the only biodegradable polymer with cationic characteristics 25–27 . This unique cationic property is due to the presence of the amino group in the body of chitosan polymer, which causes different properties in drug delivery systems.…”