A novel case of Raoultella planticola urinary tract infection

Olson, D. S.; Asare, Kingsley A.; Lyons, M. Maille; Hofinger, Diedre

doi:10.1007/s15010-012-0294-x

Cited by 58 publications

(47 citation statements)

References 16 publications

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“…Although the reports of R. planticola infection are limited, this bacterium has been reported in bloodstream infection, surgical site infection, and cystitis (2)(3)(4). Bacteremia was the most common clinical manifestation in six of the 11 R. planticola infection cases in the literature (3).…”

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First Report of bla _IMP-8 in Raoultella planticola

Tseng

Wang

Liang

et al. 2014

Antimicrob Agents Chemother

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Two carbapenem-resistant Raoultella planticola clinical isolates were isolated from patients with pneumonia and Port-A catheter-related bacteremia, respectively, in Taiwan. These isolates remained susceptible to fluoroquinolone, aminoglycoside, and colistin. Though the two isolates had the same antibiogram, plasmidic carbapenemase bla IMP-8 , class 1 integron cassette (dfrA12-orfF-aadA2), and qnrB2, they had different pulsed-field gel electrophoresis patterns, plasmid sizes, and outer membrane protein loss profiles. To our knowledge, this is the first report of bla IMP-8 found in R. planticola. Interestingly, bla IMP-8 is the most common carbapenemase found in Klebsiella pneumoniae in Taiwan. In the literature, carbapenemase genes in R. planticola in each country were also found in carbapenem-resistant Enterobacteriaceae in the same country. Raoultella planticola belongs to the Enterobacteriaceae family, is related to Klebsiella spp., and is mostly found in soil and water (1). Although the reports of R. planticola infection are limited, this bacterium has been reported in bloodstream infection, surgical site infection, and cystitis (2-4). Bacteremia was the most common clinical manifestation in six of the 11 R. planticola infection cases in the literature (3). To date, there are isolates of Raoultella ornithinolytica and R. planticola which are resistant to carbapenem and carry different carbapenemases, including bla KPC , bla , and bla OXA-162 genes (2, 5, 6). However, bla IMP-8 -producing R. planticola has not been reported in the literature.Among 411 carbapenem-resistant Enterobacteriaceae isolates collected from a nationwide surveillance study in Taiwan in 2012, two carbapenem-resistant R. planticola clinical isolates were identified from patients in the National Taiwan University Hospital. One was isolated from a sputum specimen; the other was from a blood specimen. The 16S rRNA gene sequencing confirmed identification of R. planticola initially with the Vitek 2 system (7). Case 1. A 77-year-old male patient was a case of non-small-cell lung cancer. He was admitted with pneumonia in February 2012. After admission, respiratory failure and shock developed. Chest roentgenography revealed bronchopneumonia in the right lower lung field. Sputum culture yielded carbapenem-resistant R. planticola (isolate 139), and the patient received levofloxacin and cefepime. Due to progressive leukocytosis, unstable hemodynamics, and increased O 2 demand, meropenem and colistin were prescribed instead of cefepime. The patient eventually died of pneumonia and shock.Case 2. A 57-year-old male patient had non-small-cell lung cancer with bilateral mediastinal lymph nodes and multiorgan metastasis. He received therapy with erlotinib and cisplatin. Port-A catheter-related bacteremia was suspected, and blood cultures grew Acinetobacter baumannii and carbapenem-resistant R. planticola (isolate 193). The patient received ceftazidime, levofloxacin, and gentamicin, and then the follow-up blood cultures were negative sterile 5 days later....

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First Report of bla _IMP-8 in Raoultella planticola

Tseng

Wang

Liang

et al. 2014

Antimicrob Agents Chemother

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“…Fifteen bacteremia cases were found in the literature, of which four included cholangitis. It usually affects people with significant co-morbidities (usually immunosuppressed individuals) related to trauma and/or prior invasive procedures (1)(2)(3)(4). Prognosis is good as the pathogen is sensitive to most antibiotics, although resistance has already been reported (5).…”

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Bacteremia with Raoultella planticola in the setting of acute pancreatitis complicated with acute cholangitis

2017

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“…Raoultella planticola is found to have similar pathogenetic features as Klebsiella spp. which are associated with severe infections in fragile patients, as: bacteraemias, pneumonias, and urinary tract infections (Olson et al 2013;Cho et al 2016). Common virulence factors between Klebsiella spp.…”

Section: Introductionmentioning

confidence: 99%

A new emerging oral infection: Raoultella planticola in a boy with haematological malignancy

Bardellini

Amadori

Schumacher

et al. 2017

Eur Arch Paediatr Dent

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Background Oral mucositis is a common complication in pediatric cancer patients, affecting up to 80% of children. Due to neutropenia and disruption of the mucosal barrier, chemotherapy-induced oral mucositis is often complicated by super-infections. Case report A 16-years old male with stage 3 Burkitt's lymphoma developed chemotherapy induced oral mucositis grade 3 (according to WHO scale). Ulcers were quickly growing (reaching a maximum diameter of 3 cm) and became greyish in colour, resulting in dysphagia and pain. A swab of the lesions was taken and microbiological tests were performed. The sample grew for Raoultella planticola, an encapsulated Gram-negative bacterium whose full pathogenic potential still needs to be defined. Treatment: The patient received antibiotic combination therapy with Amikacin and Ceftazidime for 8 days. Complete healing of the lesions and resolution of the symptoms were reached and he completed his antineoplastic therapy without further complications. Follow-up: Twelve months after the infection, he is alive and well, with no oral complaints. Conclusion This is the first report of a Raoultella planticola infection in a patient with chemotherapy induced oral mucositis. This type of infection must be added to the list of organisms to be considered when caring for these patients.

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A novel case of Raoultella planticola urinary tract infection

Cited by 58 publications

References 16 publications

First Report of bla _IMP-8 in Raoultella planticola

First Report of bla _IMP-8 in Raoultella planticola

Bacteremia with Raoultella planticola in the setting of acute pancreatitis complicated with acute cholangitis

A new emerging oral infection: Raoultella planticola in a boy with haematological malignancy

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A novel case of Raoultella planticola urinary tract infection

Cited by 58 publications

References 16 publications

First Report of bla IMP-8 in Raoultella planticola

First Report of bla IMP-8 in Raoultella planticola

Bacteremia with Raoultella planticola in the setting of acute pancreatitis complicated with acute cholangitis

A new emerging oral infection: Raoultella planticola in a boy with haematological malignancy

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First Report of bla _IMP-8 in Raoultella planticola

First Report of bla _IMP-8 in Raoultella planticola