A Novel Case of Concurrent T-cell and Early T-cell Lymphoblastic Lymphoma in an Adolescent Female: A Brief Report

Treinen, Charles; Arja, Mohammad Abu; Kahwash, Samir B.; Rangarajan, Hemalatha G.; Willen, Faye; Audino, Anthony

doi:10.22541/au.160526721.16243918/v1

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“…For each species in the database, we performed literature searches to collect data on multicellularity (a species was considered multicellular when the typical cell number in a group was greater or equal to four) and the presence of ECM, sometimes referred to as mucus or mucilage. The primary reference for all species was 'Växtplanktonflora' (phytoplankton flora) 76 . The second main reference was 'Algaebase' (www.algaebase.org).…”

Section: The Environments and Phenotypes Of Green Algae In Swedish Lakesmentioning

confidence: 99%

Single-cell adaptations shape evolutionary transitions to multicellularity in green algae

et al. 2023

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The evolution of multicellular life has played a pivotal role in shaping biological diversity. However, we know surprisingly little about the natural environmental conditions that favour the formation of multicellular groups. Here we experimentally examine how key environmental factors (predation, nitrogen and water turbulence) combine to influence multicellular group formation in 35 wild unicellular green algae strains (19 Chlorophyta species). All environmental factors induced the formation of multicellular groups (more than four cells), but there was no evidence this was adaptive, as multicellularity (% cells in groups) was not related to population growth rate under any condition. Instead, population growth was related to extracellular matrix (ECM) around single cells and palmelloid formation, a unicellular life-cycle stage where two to four cells are retained within a mother-cell wall after mitosis. ECM production increased with nitrogen levels resulting in more cells being in palmelloids and higher rates of multicellular group formation. Examining the distribution of 332 algae species across 478 lakes monitored over 55 years, showed that ECM and nitrogen availability also predicted patterns of obligate multicellularity in nature. Our results highlight that adaptations of unicellular organisms to cope with environmental challenges may be key to understanding evolutionary routes to multicellular life.

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Section: The Environments and Phenotypes Of Green Algae In Swedish Lakesmentioning

confidence: 99%

Single-cell adaptations shape evolutionary transitions to multicellularity in green algae

et al. 2023

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A Novel Case of Concurrent T-cell and Early T-cell Lymphoblastic Lymphoma in an Adolescent Female: A Brief Report

Abstract: This a preprint and has not been peer reviewed. Data may be preliminary.

Cited by 1 publication

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Single-cell adaptations shape evolutionary transitions to multicellularity in green algae

Single-cell adaptations shape evolutionary transitions to multicellularity in green algae

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