A Novel Carbon Quantum Dots and its Applications in Drug Delivery System – A Review. Pharmacophore

Krishnaswamy, Kathiresan; Pandian, P.

doi:10.51847/xvyp9hw9fg

Cited by 2 publications

(1 citation statement)

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“…They concluded that cell viability reduced after radiation exposure [ 167 ]. Furthermore, CQDs can be functionalized with biocompatible bio-molecules and applied as a nanocarrier for drug/gene delivery systems [ 168 ]. Wang et al modified the structure of CQDs with hyaluronic acid and carboxymethyl chitosan through a one-step hydrothermal method and applied it for doxorubicin delivery [ 169 ].…”

Section: Carbon-based Nanostructuresmentioning

confidence: 99%

Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications

Yazdani,

Mozaffarian,

Pazuki

et al. 2024

Pharmaceutics

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Gene therapeutics are promising for treating diseases at the genetic level, with some already validated for clinical use. Recently, nanostructures have emerged for the targeted delivery of genetic material. Nanomaterials, exhibiting advantageous properties such as a high surface-to-volume ratio, biocompatibility, facile functionalization, substantial loading capacity, and tunable physicochemical characteristics, are recognized as non-viral vectors in gene therapy applications. Despite progress, current non-viral vectors exhibit notably low gene delivery efficiency. Progress in nanotechnology is essential to overcome extracellular and intracellular barriers in gene delivery. Specific nanostructures such as carbon nanotubes (CNTs), carbon quantum dots (CQDs), nanodiamonds (NDs), and similar carbon-based structures can accommodate diverse genetic materials such as plasmid DNA (pDNA), messenger RNA (mRNA), small interference RNA (siRNA), micro RNA (miRNA), and antisense oligonucleotides (AONs). To address challenges such as high toxicity and low transfection efficiency, advancements in the features of carbon-based nanostructures (CBNs) are imperative. This overview delves into three types of CBNs employed as vectors in drug/gene delivery systems, encompassing their synthesis methods, properties, and biomedical applications. Ultimately, we present insights into the opportunities and challenges within the captivating realm of gene delivery using CBNs.

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Section: Carbon-based Nanostructuresmentioning

confidence: 99%