A novel carbohydrate antigen expression during development of Opisthorchis viverrini- associated cholangiocarcinoma in golden hamster: A potential marker for early diagnosis

Sawanyawisuth, Kanlayanee; Silsirivanit, Atit; Kunlabut, Kunlathida; Tantapotinan, Nattawat; Vaeteewoottacharn, Kulthida; Wongkham, Sopit

doi:10.1016/j.parint.2011.07.013

Cited by 18 publications

(12 citation statements)

References 25 publications

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“…In addition, an animal trial reported that a novel CCA-associated carbohydrate antigen may have potential as a marker for the early diagnosis of CCA. 15 Zabron et al confirmed that neutrophil gelatinase-associated lipocalin (NGAL) was a potential biomarker to distinguish benign from malignant biliary obstruction. 16 The development of modern tissue pathological technology enabled some new aspects of CCA to be studied.…”

Section: Diagnosismentioning

confidence: 99%

A review of the clinical diagnosis and therapy of cholangiocarcinoma

2013

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Cholangiocarcinoma (CCA) is the second most common primary hepatic malignancy worldwide. The incidence of intrahepatic CCA is increasing, whereas that of extrahepatic CCA is decreasing. This review looks at the new advances that have been made in the management of CCA, based on a PubMed and Science Citation Index search of results from randomized controlled trials, reviews, and cohort, prospective and retrospective studies. Aggressive interventional approaches and new histopathological techniques have been developed to make a histological diagnosis in patients with high risk factors or suspected CCA. Resectability of the tumour can now be assessed using multiple radiological imaging studies; the main prognostic factor after surgery is a histologically negative resection margin. Biliary drainage and/or portal vein embolization may be performed before extended radical resection, or liver transplantation may be undertaken in combination with neoadjuvant chemotherapy or chemoradiotherapy. Though many advances have been made in the management of CCA, the standard modality of treatment has not yet been established. This review focuses on the clinical options for different stages of CCA.

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Section: Diagnosismentioning

confidence: 99%

A review of the clinical diagnosis and therapy of cholangiocarcinoma

2013

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“…Various biomarkers have already been suggested, including overexpression of proteins orosmucoid 2 and kinesin 18A (Rucksaken et al, 2012), annexin A1 (Hongsrichan et al, 2014), and various other dysregulated proteins (Khoontawad et al, 2017). Other suggested markers, include, for example, a carbohydrate antigen associated with CCA, on which particular epitopes may be recognized using monoclonal antibody-based techniques (Sawanyawisuth et al, 2012). With regards to O. felineus, which has a different geographical distribution, the emphasis remains predominantly on control at the fish level; a landmark paper following the outbreaks in Italy summarized the treatments that could be used to inactivate the metacercariae in fish, with particular reference to the fact that one outbreak had occurred despite the fish being frozen at À10°C (Pozio et al, 2013).…”

Section: Parasite-specific Interventions: Opisthorchis Sppmentioning

confidence: 99%

Parasites in Food: From a Neglected Position to an Emerging Issue

Robertson

2018

Advances in Food and Nutrition Research

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Foodborne parasites have long been a neglected group of pathogens, as they often have insidious, chronic effects, rather than being acute diseases, and they are often associated with impoverished or marginalized populations. In addition, due to the long incubation period for most foodborne parasites, source attribution is often difficult, if not impossible. However, global trends have enabled foodborne parasites to emerge in different populations in new locations, transmitted through different food types, and sometimes with unexpected symptoms. This emergence of foodborne parasites has brought them into focus. In this chapter, six foodborne parasites are used as examples on emergence: Echinococcus multilocularis is spreading to new locations; Cryptosporidium spp. are beginning to be associated not only with water, but also with salads; Trypanosoma cruzi is being manifest with acute disease due to foodborne transmission, particularly transmitted with juices; Trichinella spp. have become less of a burden regarding transmission via pork in many countries, but now game animals are becoming a concern; anisakiasis is becoming a global problem as the world develops a taste for sushi, and similarly for opisthorchiasis, which is increasingly being associated with cholangiocarcinoma. However, the emergence of these foodborne parasites provides an incentive for increased efforts being made toward control. In this chapter, having described how the parasites are emerging from their neglected position, the focus turns toward control. In addition to considering control measures that may be applied to the specific parasites, an overview is provided of some of the organized collaborations, projects, and consortia, as well as some of their outputs, that have in focus the control of these emerging and important pathogens.

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“…Silsirivanit et al [46] and Sawanyawisuth et al [47] reported an novel CCA antigens, an unidentified glycan epitope on MUC5AC and designated as CCA-associated carbohydrate antigen (CCA-CA), which was found to be up-regulated at early stage in CCA development, suggesting the possibility of this antigen as an early diagnostic and prognostic marker of CCA.…”

Section: Biomarkers Of Opisthorchiasis-associated Ccamentioning

confidence: 99%

Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated Cholangiocarcinoma

Wu¹,

Boonmars²

2013

J Bacteriol Parasitol

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Definitive relationship has been confirmed between Opisthorchis viverrini infection and tumorigenesis of cholangiocarcinoma (CCA), by epidemiological investigation and animal experiments. In the O. viverrini endemic area, opisthorchiasis-associated CCA has been becoming a serious public health problem. Understanding of the molecular mechanisms of tumorigenesis of the infection-induced CCA will be helpful to develop new biomarkers for diagnosis and therapy. This review addresses recent progresses in molecular mechanism and biomarker of opisthorchiasisassociated CCA.

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A novel carbohydrate antigen expression during development of Opisthorchis viverrini- associated cholangiocarcinoma in golden hamster: A potential marker for early diagnosis

Cited by 18 publications

References 25 publications

A review of the clinical diagnosis and therapy of cholangiocarcinoma

A review of the clinical diagnosis and therapy of cholangiocarcinoma

Parasites in Food: From a Neglected Position to an Emerging Issue

Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated Cholangiocarcinoma

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