A novel bubble-forming material for preparing hydrophobic-agent-loaded bubbles with theranostic functionality

Yang, Pei; Tung, Fu I.; Chen, Hsiao Ping; Liu, Tse Ying; Lin, Yi

doi:10.1016/j.actbio.2014.05.008

Cited by 12 publications

(7 citation statements)

References 34 publications

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“…A theranostic system provides imaging/diagnostics and therapeutic functions simultaneously . An image‐guided smart NPs is expected to provide a suitable platform for spatial and temporal controlled delivery systems . Combined delivery of therapeutic and diagnostic agents with a single system using nanoscaled theranostic approaches paves the way for the development of tailored NSs for the early diagnosis and prevention of formidable disease and their precise detection and therapy .…”

Section: Cs‐based Theranosticsmentioning

confidence: 99%

“…studied. carboxymethyl hexanoyl CS (CHC) as a new bubble‐forming object together with SPIONs, which were used to produce bubbles with image‐guided potential for efficiently encapsulating and delivery of the hydrophobic anticancer agents to the tumor cells . They reported that the SPIONs were the main factor in receiving nanobubbles and encapsulating the camptothecin (CPT) as a hydrophobic chemotherapeutic.…”

Section: Cs‐based Theranosticsmentioning

confidence: 99%

“…6,112,113 An image-guided smart NPs is expected to provide a suitable platform for spatial and temporal controlled delivery systems. [114][115][116][117] Combined delivery of therapeutic and diagnostic agents with a single system using nanoscaled theranostic approaches paves the way for the development of tailored NSs for the early diagnosis and prevention of formidable disease and their precise detection and therapy. [118][119][120][121] Such NSs must be able to detect the disease biomarkers, bind to them with high enough affinity, and then deliver and release the suitable therapeutic dose into the target site in a kinetically sound manner.…”

Section: Cs-based Theranosticsmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

Fathi

Majidi

Zangabad

et al. 2018

Medicinal Research Reviews

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Nanotechnology as an emerging field has established inevitable impacts on nano-biomedicine and treatment of formidable diseases, inflammations, and malignancies. In this regard, substantial advances in the design of systems for delivery of therapeutic agents have emerged magnificent and innovative pathways in biomedical applications. Chitosan (CS) is derived via deacetylation of chitin as the second most abundant polysaccharide. Owing to the unique properties of CS (e.g., biocompatibility, biodegradability, bioactivity, mucoadhesion, cationic nature and functional groups), it is an excellent candidate for diverse biomedical and pharmaceutical applications such as drug/gene delivery, transplantation of encapsulated cells, tissue engineering, wound healing, antimicrobial purposes, etc. In this review, we will document, discuss, and provide some key insights toward design and application of miscellaneous nanoplatforms based on CS. The CS-based nanosystems (NSs) can be employed as advanced drug delivery systems (DDSs) in large part due to their remarkable physicochemical and biological characteristics. The abundant functional groups of CS allow the facile functionalization in order to engineer multifunctional NSs, which can simultaneously incorporate therapeutic agents, molecular targeting, and diagnostic/imaging capabilities in particular against malignancies. These multimodal NSs can be literally translated into clinical applications such as targeted diagnosis and therapy of cancer because they offer minimal systemic toxicity and maximal cytotoxicity against cancer cells and tumors. The recent developments in the CS-based NSs functionalized with targeting and imaging agents prove CS as a versatile polymer in targeted imaging and therapy.

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Section: Cs‐based Theranosticsmentioning

confidence: 99%

Section: Cs‐based Theranosticsmentioning

confidence: 99%

Section: Cs-based Theranosticsmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

Fathi

Majidi

Zangabad

et al. 2018

Medicinal Research Reviews

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“…The mechanism of ultrasound-mediated targeted delivery mainly relies on cavitation and sonication effects of ultrasonic microbubbles generated under the irradiation of ultrasonic field strength (16). Ultrasound-targeted microbubbles show various modifications in their shell membranes and they can carry a variety of drugs or genes and can bind to specific antigens or genes expressed by specific cells in the body, thus providing the possibility of ultrasound-mediated targeted treatment (17).…”

Section: Introductionmentioning

confidence: 99%

miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth

Wang

et al. 2020

Mol Med Report

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ultrasonic microbubbles in combination with microrna (mirnas/mirs) exhibited promising effects on cancer treatments. The aim was to investigate the role of miR-378 in hepatoma cells and the efficiency of it in combination with ultrasonic irradiation and SonoVue ® microbubbles method for cell transfection. HuH-7, Hep3B and SK-Hep1 cells were transfected with an miR-378 mimic using only lipofectamine ® 3000 or combined with SonoVue microbubbles and ultrasonic irradiation at 0.5 W/cm 2 for 30 sec. mRNAs and protein levels of Cyclin D1, Bcl-2, Bax, Akt, p53 and Survivin were detected by reverse transcription-quantitative PCR and western blotting, respectively. Cell survival rate, proliferation, cell cycle and apoptosis were determined by Cell Counting Kit-8, cell double cytochemical staining and flow cytometry, respectively. It was found that using a combination of ultrasonic irradiation and the SonoVue microbubbles method increased the effectiveness of mir-378 transfection into hepatocellular carcinoma (Hcc) cells, and increased the inhibition of cell survival and proliferation. Moreover, mir-378 increased the rate of apoptosis and upregulated the expression of Bax and p53, and suppressed the cell cycle and downregulated the expression of Cyclin D1, Bcl-2, Akt, β-catenin and Survivin much more effectively in the HCC cell line by applying the combined method. Thus, miR-378 was shown to be a suppressive factor to reduce proliferation and increase apoptosis in HCC cells. Additionally, the combination of ultrasonic irradiation and SonoVue microbubbles method was more efficient in the transfection of miRNA.

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“…Additionally, the applications of nanobubble/nanodroplet ultrasound imaging are currently limited to observing tumor tissue. 15,24 In this study, we designed perfluoropentane nanodroplets to investigate ultrasound-induced pharmacokinetics and development of novel diagnostic applications to improve our understanding of and ability to accurately predict the clinical applications and efficacy of echogenic bubbles.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging

Chang¹,

Hou²,

Hung

et al. 2015

IJN

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Bubble formulations have both diagnostic and therapeutic applications. However, research on nanobubbles/nanodroplets remains in the initial stages. In this study, a nanodroplet formulation was prepared and loaded with a novel class of chemotherapeutic drug, ie, quercetin, to observe its pharmacokinetic properties and ultrasonic bioimaging of specific sites, namely the abdominal vein and bladder. Four parallel groups were designed to investigate the effects of ultrasound and nanodroplets on the pharmacokinetics of quercetin. These groups were quercetin alone, quercetin triggered with ultrasound, quercetin-encapsulated in nanodroplets, and quercetin encapsulated in nanodroplets triggered with ultrasound. Spherical vesicles with a mean diameter of 280 nm were formed, and quercetin was completely encapsulated within. In vivo ultrasonic imaging confirmed that the nanodroplets could be treated by ultrasound. The results indicate that the initial 5-minute serum concentration, area under the concentration–time curve, elimination half-life, and clearance of quercetin were significantly enhanced by nanodroplets with or without ultrasound.

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A novel bubble-forming material for preparing hydrophobic-agent-loaded bubbles with theranostic functionality

Cited by 12 publications

References 34 publications

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth

Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging

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A novel bubble-forming material for preparing hydrophobic-agent-loaded bubbles with theranostic functionality

Cited by 12 publications

References 34 publications

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

miR‑378 in combination with ultrasonic irradiation and SonoVue microbubbles transfection inhibits hepatoma cell growth

Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and&nbsp;their&nbsp;use for bioimaging

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Product

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Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging