A Novel Biopolymer Nano-Complex Based on Fish Scale Collagen, Konjac Glucomannan, Camellia Chrysantha Polyphenols and Ginsenoside Rb1: Preparation, Characterization and Its Bioactivity

Ngo, Dai Quang; Nguyen, Thi Thanh Sang; Nguyễn, Tiến Dũng; Phung, Thi Lan; Trung, Vũ Quốc; Hoàng, Thái

doi:10.1007/s10924-020-02022-0

Cited by 8 publications

(3 citation statements)

References 54 publications

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“…The inhibition 50 percent of cell growth, IC 50 values of the bio-complex with KB, LU1, Hep G2, MCF7, SK-Mel-2 cancer cells were 18.01, 42, 64, 64, 47 µg mL -1 , respectively. The biocomplex did not cause toxicity on HEK-293 normal cells [59].…”

Section: Applications Of Fish Collagen In Drug Delivery Systemsmentioning

confidence: 90%

“…Fish scale collagen is used as a main composition in the bio-complexes by a combination of it with bioactive compounds such as polyphenols (extracted from Camellia chrysantha leaf) and ginsenoside Rb1 (extracted from panax notoginseng root powder) [59,60]. The bio-complex based on fish scale collagen, konjac glucomannan, Camellia chrysantha polyphenols and ginsenoside Rb1 had an average particle size of 115.4 -593.0 nm with excellent inhibition of cancer cells (epithelial carcinoma -KB, lung cancer -LU1, liver cancer -Hep G2, breast cancer -MCF7, skin cancer -SK-Mel-2 cells), anti-inflammatory and antioxidant bioactivities.…”

Section: Applications Of Fish Collagen In Drug Delivery Systemsmentioning

confidence: 99%

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Review: fish collagen: extraction, characterization and application in wound healing and drug delivery

Nguyen Thuy Chinh,

Thai Hoang

2024

Vietnam J. Sci. Technol.

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Collagen is a natural protein presenting in the animal and human’s body. It is in natural fibrous and could be found in the connective tissue and flesh of mammal, approximately 25-35 wt.% of total human protein. Collagen is abundant in fibrous tissues such as: bones, cartilage, tendons, blood vessels, ligaments, skin, cornea, aortic disc and intestines. Fish collagen is currently being studied as a new biological substitute for collagen from animals. It extracted from by-products (scales, skins, bones, etc.) by biochemical or biological methods is safe, has high adsorption, high compatible. The factors influencing on the extraction process include temperature, time, concentration of ingredients, etc. The fish collagen is usually collagen type I with a fibril structure. Each unit of collagen is tropocollagen consisting of three polypeptide chains twisted together. Depending on the source of ingredients, the composition of aminoacids, denaturation temperature, the sequence of aminoacids, structure, morphology, molecular weight, extraction yield, etc. of obtained collagens are different. This paper reviews the extraction and characterization of fish collagen from products after fish processing by chemical or biochemical methods. The applications of fish collagen in wound healing and drug delivery are also reviewed.

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Section: Applications Of Fish Collagen In Drug Delivery Systemsmentioning

confidence: 90%

Section: Applications Of Fish Collagen In Drug Delivery Systemsmentioning

confidence: 99%

Review: fish collagen: extraction, characterization and application in wound healing and drug delivery

Nguyen Thuy Chinh,

Thai Hoang

2024

Vietnam J. Sci. Technol.

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“…Nowadays, collagen from fish is attracting a lot of attention thanks to its high absorbance ability, biocompatibility, safety, high stability and absorption, good bonding effect (Yamada et al, 2014;Pati et al, 2012;Nagai et al, 2004). Collagen is a potential material for drug delivery and biomedical applications because it can form high-strength and stable fibers by its self-agglutination and crosslinking properties (Cherim et al, 2018;Lee et al, 2001;Quang et al, 2021;Trang et al, 2020;Ning et al, 2021;Subhan et al, 2021).…”

Section: Research Overviewmentioning

confidence: 99%

Some Characteristics of Fish Scale Collagen/Allopurinol Biocomposite

Nguyen¹,

Nguyen²,

Nguyen³

et al. 2023

Khoa học và Phát triển

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In this work, collagen extracted from fresh-water fish scales has been used as a matrix in the drug delivery polymeric system. Allopurinol has been applied to reduce the concentration of uric acid in blood and used as a model drug in collagen drug delivery system. The functional groups in collagen/allopurinol biocomposite as well as the morphology of this material were assessed by infrared (IR) spectroscopy and scanning electron microscopy (SEM). Allopurinol content released from collagen/allopurinol biocomposite in simulated body fluids was determined based on the optical absorbance of solutions containing drug by ultraviolet – visible (UV-Vis) spectra and allopurinol calibration equations. The analysis results of IR spectra of biocomposite samples indicated that the collagen/allopurinol biocomposite contains N–H, C–H, O–H linkages in collagen and C=O, C=N, N-H linkages in allopurinol. The SEM images showed that the morphology of collagen/allopurinol biocomposites differs to that of allopurinol. The allopurinol could release from the biocomposites in simulated body fluids (pH 2 and pH 7.4) according to two stages: fast release stage for 1 first hour and slow release stage in following hours. At the same time of testing, the content of allopurinol released from collagen/allopurinol biocomposite is higher than that from allopurinol free (allopurinol unloaded by collagen).

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Characterizations and bioactivities of novel biocomposites based on modified fish collagen, ginsenoside Rb1, and Camellia chrysantha polyphenols

Nguyen,

Duong,

Hoang

et al. 2024

J of Applied Polymer Sci

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Collagen derived from freshwater fish scales is a potential material for hemostatic and wound healing. 3D printing method is an environmentally friendly technique to geometrically‐controlled samples and is widely applied to prepare collagen‐based materials. This work aims to compare the advantages of preparation methods for hemostatic materials based on collagen, in which, the traditional method, solution will be compared with the modern method, 3D printing. Collagen in gel form was crosslinked with glutaraldehyde and was first time modified with ginsenoside Rb1 and Camellia chrysantha polyphenols. The characteristics of biomaterial samples, including functional groups, morphology, and element composition of samples have been assessed using infrared spectroscopy, energy‐dispersive x‐ray, field emission scanning electron microscopy. The swelling degree and hemostatic ability of biomaterial samples prepared according to two methods would be tested. The antibacterial, anti‐inflammatory tests, and in vivo test on mice were carried out on these biomaterials. The findings confirmed that the 3D printing method with direct ink writing technique is more suitable for the preparation of hemostatic collagen‐based membrane than the solution method. The time to hemostasis when using collagen‐based membrane was found to be 104.0 ± 16.7 s. Moreover, the collagen‐based biomaterials also have anti‐inflammatory and antibacterial activity. This opens potential applications of the biomaterials from fish scale collagen in practice.

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A Novel Biopolymer Nano-Complex Based on Fish Scale Collagen, Konjac Glucomannan, Camellia Chrysantha Polyphenols and Ginsenoside Rb1: Preparation, Characterization and Its Bioactivity

Cited by 8 publications

References 54 publications

Review: fish collagen: extraction, characterization and application in wound healing and drug delivery

Review: fish collagen: extraction, characterization and application in wound healing and drug delivery

Some Characteristics of Fish Scale Collagen/Allopurinol Biocomposite

Characterizations and bioactivities of novel biocomposites based on modified fish collagen, ginsenoside Rb1, and Camellia chrysantha polyphenols

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