A novel bioelectrochemical interface based on in situ synthesis of gold nanostructures on electrode surfaces and surface activation by Meerwein's salt. A bioelectrochemical sensor for glucose determination

Nikolaev, Konstantin G.; Ermakov, S. S.; Ermolenko, Yu. Е.; Averyaskina, E. O.; Offenhäusser, Andreas; Mourzina, Yulia

doi:10.1016/j.bioelechem.2015.05.004

Cited by 30 publications

(17 citation statements)

References 73 publications

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“…Similar parameters were found earlier for the gold nanostructures grown on the gold thin-film electrodes in situ by the same methods of synthesis and cleaning proving that there was no inhibition of the electron transfer due to the surface impurities [28]. However, the peak separations for these redox couples on the Au NWs network electrode increase to 152 mV (Ep,c= 0.173 V, Ep,a= 0.325 V) and 485 mV (Ep,c= -0.007 V, Ep,a= 0.478 V) for ferrocene methanol and hexacyanoferrate respectively, due to the potential drop along the Au NWs network.…”

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confidence: 85%

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On “resistance overpotential” caused by a potential drop along the ultrathin high aspect ratio gold nanowire electrodes in cyclic voltammetry

Muratova

Mikhelson

Ermolenko

et al. 2016

J Solid State Electrochem

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High aspect ratio ultrathin (d10 nm) gold nanowires deposited on Si/SiO2 substrate are used as working electrodes for measuring cyclic voltammograms (CVs) in aqueous solutions of ferrocene methanol and potassium hexacyanoferrate(III). The broadening of the peak separation as compared with that at a solid working electrode is explained as a result of the potential drop ("resistance overpotential") along nanowires and nanowire network. The change in the CV shape over a sequence of scans is ascribed to a gradual breakup of individual nanowires and the respective transition of the linear diffusion to hemispherical diffusion regularities.

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confidence: 85%

“…The gold nanowires were synthesized following the procedure described elsewhere [1,28], with minor modifications. The cleaned Si/SiO2 substrates were placed into the reaction vessel.…”

Section: Synthesis Of Nanowiresmentioning

confidence: 99%

On “resistance overpotential” caused by a potential drop along the ultrathin high aspect ratio gold nanowire electrodes in cyclic voltammetry

Muratova

Mikhelson

Ermolenko

et al. 2016

J Solid State Electrochem

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“…However, nanomaterials always form close-packed structures after they are assembled on electrode surface, which hinders their performance greatly232425262728. Furthermore, most of GOD-based biosensors detect glucose level via monitoring the consumption of O 2 in enzymatic reaction29. So, the nanomaterials are used not only as a supporting to load GOD molecules but also as a catalyst for the reduction of O 2 in which the amount of O 2 consumed in the enzymatic reaction could be explored193031.…”

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confidence: 99%

Smart Nanocomposites of Cu-Hemin Metal-Organic Frameworks for Electrochemical Glucose Biosensing

Yang

Zhang

et al. 2016

Sci Rep

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Herein, a smart porous material, Cu-hemin metal-organic-frameworks (Cu-hemin MOFs), was synthesized via assembling of Cu2+ with hemin to load glucose oxidase (GOD) for electrochemical glucose biosensing for the first time. The formation of the Cu-hemin MOFs was verified by scanning electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, N2 adsorption/desorption isotherms, UV-vis absorption spectroscopy, fluorescence spectroscopy, thermal analysis and electrochemical techniques. The results indicated that the Cu-hemin MOFs showed a ball-flower-like hollow cage structure with a large specific surface area and a large number of mesopores. A large number of GOD molecules could be successfully loaded in the pores of Cu-hemin MOFs to keep their bioactivity just like in a solution. The GOD/Cu-hemin MOFs exhibited both good performance toward oxygen reduction reaction via Cu-hemin MOFs and catalytic oxidation of glucose via GOD, superior to other GOD/MOFs and GOD/nanomaterials. Accordingly, the performance of GOD/Cu-hemin MOFs-based electrochemical glucose sensor was enhanced greatly, showing a wide linear range from 9.10 μM to 36.0 mM and a low detection limit of 2.73 μM. Moreover, the sensor showed satisfactory results in detection of glucose in human serum. This work provides a practical design of new electrochemical sensing platform based on MOFs and biomolecules.

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“…A wide range of materials and compounds with selective binding and/or electrocatalytic properties, which favor the thermodynamics and kinetics of specific redox processes, have been used to lower the absolute value of the response potential and improve the sensitivity and selectivity of these types of sensors (Yogeswaran and Chen, 2008 ; Budnikov et al, 2012 ; Thiyagarajan et al, 2014 ; Komkova et al, 2017 ). These include enzymes as biocatalysts (Heller and Feldman, 2008 ; Koposova et al, 2014 , 2015 ; Nikolaev et al, 2015 ; Rocchitta et al, 2016 ; Quesada-González and Merkoçi, 2017 ; Bandodkar et al, 2018 ). However, there are some general problems associated with highly selective electrochemical sensors, where selectivity is achieved by enzymes such as the low stability of biosensors, restricted measurement conditions, the use of onerous immobilization procedures, and mediators, as well as poor compatibility with nanotechnology processing.…”

Section: Introductionmentioning

confidence: 99%

Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions

et al. 2018

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The development of electrochemical multisensor systems is driven by the need for fast, miniature, inexpensive, analytical devices, and advanced interdisciplinary based on both chemometric and (nano)material approaches. A multicomponent analysis of complex mixtures in environmental and technological monitoring, biological samples, and cell culture requires chip-based multisensor systems with high-stability sensors. In this paper, we describe the development, characterization, and applications of chip-based nanoelectrochemical sensor arrays prepared by the directed electrochemical nanowire assembly (DENA) of noble metals and metal alloys to analyze aqueous solutions. A synergic action of the electrode transducer function and electrocatalytic activity of the nanostructured surface toward analytes is achieved in the assembled metal nanowire (NW) sensors. Various sensor nanomaterials (Pd, Ni, Au, and their multicomponent compositions) can be electrochemically assembled on a single chip without employing multiple cycles of photolithography process to realize multi-analyte sensing applications as well as spatial resolution of sensor analysis by this single-chip multisensor system. For multi-analyte electrochemical sensing, individual amperometric signals of two or more nanowires can be acquired, making use of the specific electrocatalytic surface properties of the individual nanowire sensors of the array toward analytes. To demonstrate the application of a new electrochemical multisensor platform, Pd-Au, Pd-Ni, Pd, and Au NW electrode arrays on a single chip were employed for the non-enzymatic analysis of hydrogen peroxide, glucose, and ethanol. The analytes are determined at low absolute values of the detection potentials with linear concentration ranges of 1.0 × 10−6 − 1.0 × 10−3 M (H2O2), 1.5 × 10−7 − 2.0 × 10−3 M (glucose), and 0.7 × 10−3 − 3.0 × 10−2 M (ethanol), detection limits of 2 × 10−7 M (H2O2), 4 × 10−8 M (glucose), and 5.2 × 10−4 M (ethanol), and sensitivities of 18 μA M−1 (H2O2), 178 μA M−1 (glucose), and 28 μA M−1 (ethanol), respectively. The sensors demonstrate a high level of stability due to the non-enzymatic detection mode. Based on the DENA-assembled nanowire electrodes of a compositional diversity, we propose a novel single-chip electrochemical multisensor platform, which is promising for acquiring complex analytical signals for advanced data processing with chemometric techniques aimed at the development of electronic tongue-type multisensor systems for flexible multi-analyte monitoring and healthcare applications.

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A novel bioelectrochemical interface based on in situ synthesis of gold nanostructures on electrode surfaces and surface activation by Meerwein's salt. A bioelectrochemical sensor for glucose determination

Cited by 30 publications

References 73 publications

On “resistance overpotential” caused by a potential drop along the ultrathin high aspect ratio gold nanowire electrodes in cyclic voltammetry

On “resistance overpotential” caused by a potential drop along the ultrathin high aspect ratio gold nanowire electrodes in cyclic voltammetry

Smart Nanocomposites of Cu-Hemin Metal-Organic Frameworks for Electrochemical Glucose Biosensing

Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions

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