A novel biocompatible PDA/IR820/DAP coating for antibiotic/photodynamic/photothermal triple therapy to inhibit and eliminate Staphylococcus aureus biofilm

Targeting implant-associated infections: titanium surface loaded with antimicrobial

“…The implant and animal characteristics of the included studies are detailed in Table 1 . All included articles were published between 2003 ( Lucke et al., 2003 ) and 2020 ( Auñón et al., 2020 ; Zeng et al., 2020 ), in twenty-four different countries. Among the implant materials, pure Ti, and titanium-aluminum-vanadium (Ti-Al-V), and titanium-aluminum-niobium (TiAlNb) alloys were used, and different surface treatments were evaluated.…”

“…(2016) cpTi Nanotubes Gentamicin Lyophilization + Vacuum-drying Rat 9 F S. aureus (ATCC 25923) 6w Yuan et al. (2018) cpTi Machined Vancomycin Soaking method on nanotubes coating + catechol functionalization Rat 6 F S. aureus (ATCC 25923) 4w Zeng et al. (2020) cpTi Machined +NIR light Daptomycin Immobilization with IR820 dye on PDA nanocoating Rat NR T S. aureus (ATCC 25923) 2w Zhang et al.…”

“…(2016) NR 91.45 μg (57 h) CFU/implant Ti-C: 6.7×10 5 (±7.55×10 4 ) NT-C: 4.6×10 5 (±6.24×10 4 ) 1.57×10 4 (±2.08×10 3 ) NT: ~97.7% T: ~96.6% NR <.01 Yuan et al. (2018) NR 81.7% (24 h in the presence of S. aureus ) CFU/implant (Log 10 ) 3.43 (±0.12) 0.90 (±0.43) ~73.8% NR <.01 Zeng et al. (2020) 634.6 μg 408.3 μg (14 d) CFU/implant Ti-C - NIR: 192.5 (±12.5) Ti-C + NIR: 182.5 (±22.5) T - NIR: 82.5 (±10.0) T + NIR: 5.00 (±2.5) NIR − : ~57.1% NIR + : ~97.3% NR <.01 (Ti-C versus T) <.05 (T - NIR versus T + NIR) Zhang et al.…”

Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo

“…PDA is the self-polymerized product of dopamine in an alkaline aqueous solution in the dark. Previous research confirmed that polydopamine can powerfully adhere to a large variety of material surfaces and apparently enhance hydrophilicity and biocompatibility, which is a universal method to functionalize material surfaces (Ku et al, 2010;Zeng et al, 2020;Owji et al, 2021;Tang et al, 2021). More importantly, PDA has been successfully applied to immobilize bioactive agents on implant surfaces because of numerous chemical functional groups, especially imine, amine, and catechol groups.…”

“…By assembling multiple bioactive factors on the surface, the implant would become multifunctional. Among these methods, one of the bioinspired methods, polydopamine (PDA), has attracted the attention of researchers because of its simplicity, convenience, and efficiency ( Jin et al, 2020 ; Zeng et al, 2020 ; Tang et al, 2021 ; Wang et al, 2021 ; Zhuang et al, 2021 ).…”