A novel biochip technology for detection of explosives–TNT: Synthesis, characterisation and application

Larsson, Andréas; Angbrant, Johan; Ekeroth, Johan; Månsson, Per; Liedberg, Bo

doi:10.1016/j.snb.2005.07.025

Cited by 63 publications

(36 citation statements)

References 42 publications

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“…Also, TNT biosensor based on an anti-TNT antibody was reported using a displacement assay of the surface-confi ned antibody by the TNT, and readout of the detachment of the antibody by surface plasmon resonance (SPR) [ 16 , 17 ] or quartz crystal microbalance (QCM). [ 17 ] Also, the aggregation of donor-modifi ed Au nanoparticles in the presence of the TNT acceptor substrate was used for the optical detection of TNT. [ 18 ] Quantum dots were, similarly, applied for the development of TNT [ 19 ] or RDX [ 20 ] luminescence biosensors.…”

mentioning

confidence: 99%

Functionalized CdSe/ZnS QDs for the Detection of Nitroaromatic or RDX Explosives

et al. 2012

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Chemically modified CdSe/ZnS quantum dots (QDs) are used as fluorescent probes for the analysis of explosives, and specifically, the detection of trinitrotoluene (TNT) or trinitrotriazine (RDX). The QDs are functionalized with electron-donating ligands that bind nitro-containing explosives, exhibiting electron-acceptor properties, to the QD surface, via supramolecular donor-acceptor interactions leading to the quenching of the luminescence of the QDs.

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confidence: 99%

Functionalized CdSe/ZnS QDs for the Detection of Nitroaromatic or RDX Explosives

et al. 2012

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“…The silicalite MFI-type zeolite selective explosives absorber discussed above was grown on the end of an optical fiber, and the explosives were detected using changes in refractive index (or optical thickness) [67]. Tait and colleagues coated a fiber Bragg grating with polymer materials, and detected the expansion of the polymer when it adsorbs the target molecule via the changes in the Bragg grating period [150].…”

Section: Other Spectroscopic Methodsmentioning

confidence: 99%

“…Larsson and colleagues demonstrated a novel biochip for TNT detection using self-assembled monolayers (SAMs) of hydroxyl-terminated oligo(ethylene glycol)-thiols containing three different TNT analogues in different proportions and either surface plasmon resonance (SPR) or quartz crystal microbalance (QCM) transduction [67]. The detection limit was found to fall in the 1-10 ng/mL range in liquids, and the analysis times were 100-400 s. An alternative transduction scheme uses field effect transistors (FET) based on organic materials.…”

Section: Nanotechnologymentioning

confidence: 99%

Recent Advances in Trace Explosives Detection Instrumentation

2007

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There has been a huge increase in instrument development for trace detection of explosives in the past 3 years. This is especially true for methods that can be used at a stand off distance, driven by the frightening increase in the use of improvised explosive devices in both suicide and road side bombings. This review attempts to outline and enumerate these recent developments, with details about the improvements made as well as where further improvements might come.

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“…(21) Oligo(ethylen glycol)-alkylthiols terminated with a hydroxyl group and a TNT analogue were synthesized and the sensor surface was modified with mixed SAMs using the synthesized chemicals. Their measurement procedure is different from our procedure.…”

Section: Comparison Of Two Measurement Proceduresmentioning

confidence: 99%

Displacement Immunosensor Based on Surface Plasmon Resonance for Rapid and Highly Sensitive Detection of 2,4,6-Trinitrotoluene

Onodera¹,

Mizuta

Kazuhiko

et al. 2011

Sensors and Materials

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By making use of the antigen-antibody interaction and a surface plasmon resonance (SPR) sensor, we developed a measurement procedure of displacement immunoassay to rapidly detect 2,4,6-trinitrotoluene (TNT). In this procedure, TNT solutions were injected in 30 s at the end of flowing an anti-TNT antibody. Three kinds of sensor surfaces were modified with TNT analogues, namely, TNP-glycine, DNP-glycine, and DNP-acetic acid in a self-assembled monolayer containing ethylene glycol. We investigated which of the TNT analogues provided higher sensitivity using the displacement immunosensor. As a result, the limit of detection (LOD) of TNT was 0.4 ng/mL (ppb) when using the DNP-glycine-modified Au sensor surface with a oneminute flow of TNT solution. We concluded that the final TNT LOD was 0.9 ppb on the basis of experiments using the three different DNP-glycine-modified sensor surfaces. The LOD was 0.7 ppb when using the sensorgram slope 10 s after TNT injection. The displacement immunosensor can detect TNT at sub-ppb levels in 12 s.

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A novel biochip technology for detection of explosives–TNT: Synthesis, characterisation and application

Cited by 63 publications

References 42 publications

Functionalized CdSe/ZnS QDs for the Detection of Nitroaromatic or RDX Explosives

Functionalized CdSe/ZnS QDs for the Detection of Nitroaromatic or RDX Explosives

Recent Advances in Trace Explosives Detection Instrumentation

Displacement Immunosensor Based on Surface Plasmon Resonance for Rapid and Highly Sensitive Detection of 2,4,6-Trinitrotoluene

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