A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

Nakayama, Masaaki; Nakano, Hirofumi; Hamada, Hiromi; Itami, Noritomo; Nakazawa, Ryoichi; Ito, Sadayoshi

doi:10.1093/ndt/gfq196

Cited by 87 publications

(69 citation statements)

References 32 publications

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“…The systolic blood pressure dropped in a significant number of patients to a value of 140 mm Hg. The authors think that the hypotensive effect of H 2 is due to its anti-oxidant activity and to elimination of ROS including peroxynitrate, a substance that causes renal hypertension through the reduction of nitrosyl radicals [48]. In summary, haemodialysis with ERAW improves the inflammatory response and the control of blood pressure in haemodialysis patients.…”

Section: Haemodialysismentioning

confidence: 99%

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Henry

Chambron

2013

Water

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Abstract:The consumption of alkaline reduced water produced by domestic electrolysis devices was approved in Japan in 1965 by the Ministry of Health, Labour and Welfare for the cure of gastro-intestinal disorders. Today, these devices are freely available in several countries and can be easily purchased without reserve. The commercial information included with the device recommends the consumption of 1-1.5 L of water per day, not only for gastro-intestinal disorders but also for numerous other illnesses such as diabetes, cancer, inflammation, etc. Academic research in Japan on this subject has been undergoing since 1990 only but has established that the active ingredient is dissolved dihydrogen that eliminates the free radical HO• in vivo. In addition, it was demonstrated that degradation of the electrodes during functioning of the device releases very reactive nanoparticles of platinum, the toxicity of which has not yet been clearly proven. This report recommends alerting health authorities of the uncontrolled availability of these devices used as health products, but which generate drug substances and should therefore be sold according to regulatory requirements.

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Section: Haemodialysismentioning

confidence: 99%

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Henry

Chambron

2013

Water

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“…It is thought that the latter contribution is greater, and the possible effectiveness of the prevention of CVD events by long-term EW-HD treatment was suggested. Nakayama et al reported that EW-HD ameliorated inflammatory reactions and offered a novel therapeutic option for control of uremia [17]. Huang et al reported that 1-year treatment improved T cell damage [18].…”

Section: Discussionmentioning

confidence: 99%

Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study

Maeda¹,

Yoshizaki²,

Iida³

et al. 2016

Ren Replace Ther

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“…H 2 can reach relatively high concentrations quickly, and excessive H 2 can be eliminated from the body via breathing, causing no side effects ). In addition, therapeutic H 2 effects on humans have been reported for diabetes mellitus type 2 (Imai et al, 2008), hemodialysis (Nakayama et al, 2010), inflammatory myopathies (Ito et al, 2011), radiotherapy for liver cancer (Kang et al, 2011), and acute erythematous skin diseases (Ono et al, 2012). H 2 can be administered through intravenous injection or drink.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

Zhao

Wang

Qin

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs in plastic surgery. The mechanisms of I/R injury include hypoxia, inflammation, and oxidative damage. Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger. Here, we assessed the protective effect of hydrogen-rich saline (HRS) on skin flap I/R injury. Methods: Abdominal skin flaps of rats were elevated and ischemia was induced for 3 h; subsequently, HRS or physiological saline was administered intraperitoneally 10 min before reperfusion. On postoperative Day 5, flap survival, blood perfusion, the accumulation of reactive oxygen species (ROS), and levels of cytokines were evaluated. Histological examinations were performed to assess inflammatory cell infiltration. Results: Skin flap survival and blood flow perfusion were improved by HRS relative to the controls. The production of malondialdehyde (MDA), an indicator of lipid peroxidation, was markedly reduced. A multiplex cytokine assay revealed that HRS reduced the elevation in the levels of inflammatory cytokines, chemokines and growth factors, with the exception of RANTES (regulated on activation, normal T-cell expressed and secreted) growth factor. HRS treatment also reduced inflammatory cell infiltration induced by I/R injury. Conclusions: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin flap survival.

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A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

Abstract: Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

Cited by 87 publications

References 32 publications

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW)

Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

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