A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording

Wijdenes, Pierre; Ali, Hasan; Armstrong, Ryden; Zaidi, Wali; Dalton, Colin; Syed, Naweed I.

doi:10.1038/srep34553

Cited by 16 publications

(21 citation statements)

References 27 publications

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“…Floating, untethered MEAs (Figure A) have also shown promise in reducing FBR severity (Figure ,F4,F5) . Other applications of geometric manipulation have been utilized to increase biocompatibility, such as creating synapse like structures (i.e., “nanoedges” mimicking the post synaptic cleft), and precise curvatures to increase electrical activity, though these are generally limited to surface features on planar electrodes, including topography and surface chemistry.…”

Section: Microelectrode Array Modifications For Improving the Neural mentioning

confidence: 99%

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Ferguson

Sharma

Ross

et al. 2019

Adv Healthcare Materials

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Though neural interface systems (NISs) can provide a potential solution for mitigating the effects of limb loss and central nervous system damage, the microelectrode array (MEA) component of NISs remains a significant limiting factor to their widespread clinical applications. Several strategies can be applied to MEA designs to increase their biocompatibility. Herein, an overview of NISs and their applications is provided, along with a detailed discussion of strategies for alleviating the foreign body response (FBR) and abnormalities seen at the interface of MEAs and the brain tissue following MEA implantation. Various surface modifications, including natural/synthetic surface coatings, hydrogels, and topography alterations, have shown to be highly successful in improving neural cell adhesion, reducing gliosis, and increasing MEA longevity. Different MEA surface geometries, such as those seen in the Utah and Michigan arrays, can help alleviate the resultant FBR by reducing insertion damage, while providing new avenues for improving MEA recording performance and resolution. Increasing overall flexibility of MEAs as well as reducing their stiffness is also shown to reduce MEA induced micromotion along with FBR severity. By combining multiple different properties into a single MEA, the severity and duration of an FBR postimplantation can be reduced substantially.

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Section: Microelectrode Array Modifications For Improving the Neural mentioning

confidence: 99%

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Ferguson

Sharma

Ross

et al. 2019

Adv Healthcare Materials

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“…Based on the initial computation and simulation parameters, micro-electrodes were designed and fabricated to record from brain tissue in vitro. Standard gold planar microelectrodes were first fabricated using conventional photolithography techniques 26 (Fig. 2 a, i to iii).…”

Section: Resultsmentioning

confidence: 99%

Three dimensional microelectrodes enable high signal and spatial resolution for neural seizure recordings in brain slices and freely behaving animals

Wijdenes

Haider

Gavrilovici

et al. 2021

Sci Rep

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Neural recordings made to date through various approaches—both in-vitro or in-vivo—lack high spatial resolution and a high signal-to-noise ratio (SNR) required for detailed understanding of brain function, synaptic plasticity, and dysfunction. These shortcomings in turn deter the ability to further design diagnostic, therapeutic strategies and the fabrication of neuro-modulatory devices with various feedback loop systems. We report here on the simulation and fabrication of fully configurable neural micro-electrodes that can be used for both in vitro and in vivo applications, with three-dimensional semi-insulated structures patterned onto custom, fine-pitch, high density arrays. These microelectrodes were interfaced with isolated brain slices as well as implanted in brains of freely behaving rats to demonstrate their ability to maintain a high SNR. Moreover, the electrodes enabled the detection of epileptiform events and high frequency oscillations in an epilepsy model thus offering a diagnostic potential for neurological disorders such as epilepsy. These microelectrodes provide unique opportunities to study brain activity under normal and various pathological conditions, both in-vivo and in in-vitro, thus furthering the ability to develop drug screening and neuromodulation systems that could accurately record and map the activity of large neural networks over an extended time period.

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“…Furthermore, nanotechnology coupled to microtechnology might also develop a special electrode to record activity. With regard to this, in 2016, Wijdenes et al designed a neuro-electronic hybrid technology and a planar microelectrode array with nanoedges (between 5 to 15 nm height and 2 to 3 μm width) for high fidelity recording at around 15 times higher resolution than normal planar electrode and long-term signal recording (≥30 days) of cultured neurons [ 55 ]. As neuronal cell adhesion and strong contact with the recording site are fundamentals of longer sustainable recording, a conventional 3D electrode cannot be used for longer time recording.…”

Section: Nanotechnology For Neuronal Researchmentioning

confidence: 99%

“…The planer nanoedge microelectrode reserves and maintains contact with neurons by preventing their migration away from electrodes but, at the same time, did not limit the neuron movement caused by physical tension. Thus, neuronal integrity was not compromised, which enabled the neuronal recording for a longer time (at least two weeks) [ 55 ].…”

Section: Nanotechnology For Neuronal Researchmentioning

confidence: 99%

Nanotechnology Facilitated Cultured Neuronal Network and Its Applications

Singh

Mishra

Song

et al. 2021

IJMS

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The development of a biomimetic neuronal network from neural cells is a big challenge for researchers. Recent advances in nanotechnology, on the other hand, have enabled unprecedented tools and techniques for guiding and directing neural stem cell proliferation and differentiation in vitro to construct an in vivo-like neuronal network. Nanotechnology allows control over neural stem cells by means of scaffolds that guide neurons to reform synaptic networks in suitable directions in 3D architecture, surface modification/nanopatterning to decide cell fate and stimulate/record signals from neurons to find out the relationships between neuronal circuit connectivity and their pathophysiological functions. Overall, nanotechnology-mediated methods facilitate precise physiochemical controls essential to develop tools appropriate for applications in neuroscience. This review emphasizes the newest applications of nanotechnology for examining central nervous system (CNS) roles and, therefore, provides an insight into how these technologies can be tested in vitro before being used in preclinical and clinical research and their potential role in regenerative medicine and tissue engineering.

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A novel bio-mimicking, planar nano-edge microelectrode enables enhanced long-term neural recording

Cited by 16 publications

References 27 publications

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Three dimensional microelectrodes enable high signal and spatial resolution for neural seizure recordings in brain slices and freely behaving animals

Nanotechnology Facilitated Cultured Neuronal Network and Its Applications

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