A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer

Lv, Wei; Shen, Yamei; Yang, Hengli; Yang, Rui; Cai, Wenbin; Zhang, Jian; Yuan, Lijun; Duan, Yun-you; Zhang, Li

doi:10.1155/2018/6202876

Cited by 12 publications

(12 citation statements)

References 39 publications

(37 reference statements)

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“…Nanobubbles have been widely used in ultrasound molecular imaging and drug/gene targeting delivery. When conjugated with specific ligands, nanobubbles can be used as a probe in ultrasound molecular imaging of various diseases, such as tumor (Lv et al, 2018), allograft rejection (Liu et al, 2018), and so on. Compared with microbubbles, nanobubbles can migrate from vasculature to the extravascular target site, which greatly expanded the application range of ultrasound molecular imaging.…”

Section: Discussionmentioning

confidence: 99%

The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging

et al. 2019

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Nanobubbles with a size of less than 1 µm can be used as ultrasound contrast agents for diagnosis and as drug/gene carriers for therapy. However, the optimal method of preparing uniform-sized nanobubbles is considered controversial. In this study, we developed novel biocompatible nanobubbles by performing differential centrifugation to isolate the relevant subpopulation from the parent suspensions. Compared with the method of modulating the thickness of the phospholipid film without centrifugation, nanobubbles fabricated under optimal centrifugation conditions exhibited a uniform bubble size, good stability, and low toxicity. Using in vitro ultrasound imaging, nanobubbles displayed excellent enhancement ability, which was comparable to microbubbles. In an in vivo experiment, the video intensity of nanobubbles in tumors was stronger than that of microbubbles at different times (5 min, 163.5 ± 8.3 a.u. vs. 143.2 ± 7.5 a.u., P < 0.01; 15 min, 125.4 ± 5.2 a.u. vs. 97.3 ± 4.6 a.u., P < 0.01). Fluorescence imaging obtained by confocal laser scanning microscopy demonstrated that obviously more nanobubbles passed through the vessel wall into the extravascular and intercellular space of tumors, compared with microbubbles. In conclusion, this optimized preparation method will strongly promote the application of nanobubbles in imaging and therapy.

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Section: Discussionmentioning

confidence: 99%

The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging

et al. 2019

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“…In vitro and in vivo experiments demonstrated that the obtained Y1Rmediated fluorescent nanobubbles had good ultrasound contrast enhancement and targeting ability to Y1 receptors-overexpressing breast cancer. Near-infrared (NIR) heptamethine cyanine dyes with fluorescence property and tumor-targeting characteristic, such as IR-780 [42,43] and IR-783 [44], are loaded into the shell of nanobubbles for tumor-specific ultrasound/ fluorescence dual-modal imaging. For example, Shen et al synthetized a novel targeted bimodal nanobubbles, FA-NBs-IR780, with a uniform nano-size (591 ± 52 nm) [43].…”

Section: Micro/nanobubbles Mediated Multimodal Imagingmentioning

confidence: 99%

Micro/Nanobubbles Driven Multimodal Imaging and Theragnostics of Cancer

Zhang¹,

Dai²

2021

Advanced Ultrasound in Diagnosis and Therapy

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Ultrasound imaging has attracted great interest of researchers due to their application in cancer diagnosis and treatment. Ultrasound contrast agents, microbubbles and nanobubbles are widely explored as a multifunctional platform, not only carrying other contrast agents for multimodal imaging to complement the disadvantages of each imaging modality, but also carrying drug/gene for cancer theragnostic. In this article, the characteristics and differences of microbubbles and nanobubbles are briefly introduced and reviewed. Besides, the microbubbles and nanobubbles driven multimodal imaging and theragnostic of cancer are summarized.

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“…NB can extravasate through the vascular wall into the extravascular space [22] and can easily accumulate in the tumour due to the EPR effect. Moreover, NB was established connections with HER2 a body and a near-infra uorescent dye IR783 to enable the formation of nanobubble-IR783-a body [23,24] which markedly targets HER2-positive breast cancer and could be applied in targeting drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

The combined effect of nanobubble-IR783-HPPH- affibody complex and laser on HER2-positive breast cancer

Zhang

Cai²,

et al. 2022

Preprint

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Introduction: Nanobubble is an innovative ultrasound contrast agent that triggers the development of targeted imaging of HER2-positive breast cancer by combining with HER2 affibody and IR783. HPPH is a second-generation photosensitiser that is effective in treating tumours. Hence, the nanobubble-IR783-HPPH-affibody (NIHA) complex demonstrates considerable potential in the treatment of HER2-positive breast cancer. Methods: We fabricated the NIHA complex via an advanced thin-film hydration method and detected its characteristics such as particle size, morphology, and stability cytotoxicity. Moreover, the effect of NIHA complex with laser on HER2-positive breast cancer was confirmed via in vitro and in vivo experiments. Results: The NIHA complex was spheroid, stable, and exhibited no evident cytotoxicity; moreover, its particle size was 524.8 ± 53.3 nm (n = 5). In combination with laser treatment, NIHA complex reduced the cell viability and tumour volume, induced apoptosis of HER2-positive breast cancer cells, and prolonged survival of nude mice. Conclusion: The newly prepared NIHA complex with laser treatment Have the potential on treating HER2-positive breast cancer.

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A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer

Cited by 12 publications

References 39 publications

The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging

The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging

Micro/Nanobubbles Driven Multimodal Imaging and Theragnostics of Cancer

The combined effect of nanobubble-IR783-HPPH- affibody complex and laser on HER2-positive breast cancer

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