A novel bifunctional Ti(IV) complex catalyzed asymmetric silylcyanation of aldehydes

International audienceThis review surveys the recent developments in enantioselective titanium-catalyzed cyanation reactions of carbonyl compounds, covering the literature since the beginning of 2008. It well demonstrates that this reaction constitutes an important tool in organic synthesis, still attracting a considerable interest due to the potential use of enantiopure cyanohydrins as natural products and useful synthetic intermediates in the synthesis of biologically active molecules

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ChemInform Abstract: A Novel Bifunctional Ti(IV) Complex Catalyzed Asymmetric Silylcyanation of Aldehydes.

Tang¹,

Zhang²

2011

ChemInform

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A Novel Bifunctional Ti(IV) Complex Catalyzed Asymmetric Silylcyanation of Aldehydes. -A novel Lewis acid and Lewis base bifunctional Ti(IV) complex is formed in situ by treatment of synthesized BINOL ligand with isopropyl titanate(IV), which is an efficient catalyst in the asymmetric trimethylsilylcyanation of aldehydes. Only moderate enantioselectivities are observed even though the reaction conditions are optimized. -(TANG, H.; ZHANG*, Z.; Heteroat. Chem. 22 (2011) 1, 31-35, http://dx.

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A novel bifunctional Ti(IV) complex catalyzed asymmetric silylcyanation of aldehydes

Abstract: A novel Lewis acid and Lewis base bifunctional Ti(IV) complex was formed in situ upon the treatment of ligand (R)-3,3 -bis(diphenylphosphinoyl)-BINOL with Ti(PrO-i)

Cited by 4 publications

References 39 publications

Bifunctional and Synergistic Catalysis: Lewis Acid Catalysis and Lewis Base‐Assisted Bond Polarization (n→ σ^*)

Bifunctional and Synergistic Catalysis: Lewis Acid Catalysis and Lewis Base‐Assisted Bond Polarization (n→ σ^*)

Enantioselective Titanium‐Catalyzed Cyanation Reactions of Carbonyl Compounds

ChemInform Abstract: A Novel Bifunctional Ti(IV) Complex Catalyzed Asymmetric Silylcyanation of Aldehydes.

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A novel bifunctional Ti(IV) complex catalyzed asymmetric silylcyanation of aldehydes

Abstract: A novel Lewis acid and Lewis base bifunctional Ti(IV) complex was formed in situ upon the treatment of ligand (R)-3,3 -bis(diphenylphosphinoyl)-BINOL with Ti(PrO-i)

Cited by 4 publications

References 39 publications

Bifunctional and Synergistic Catalysis: Lewis Acid Catalysis and Lewis Base‐Assisted Bond Polarization (n→ σ*)

Bifunctional and Synergistic Catalysis: Lewis Acid Catalysis and Lewis Base‐Assisted Bond Polarization (n→ σ*)

Enantioselective Titanium‐Catalyzed Cyanation Reactions of Carbonyl Compounds

ChemInform Abstract: A Novel Bifunctional Ti(IV) Complex Catalyzed Asymmetric Silylcyanation of Aldehydes.

Contact Info

Product

Resources

About

Bifunctional and Synergistic Catalysis: Lewis Acid Catalysis and Lewis Base‐Assisted Bond Polarization (n→ σ^*)

Bifunctional and Synergistic Catalysis: Lewis Acid Catalysis and Lewis Base‐Assisted Bond Polarization (n→ σ^*)