A novel base-promoted intramolecular cyclization approach for the synthesis of benzofurans, benzothiophenes and indoles

Zhang, Qianqian; Nie, Hanyu; Zhang, Kun; Huang, He; Song, Chuanjun

doi:10.1016/j.tet.2022.132815

Cited by 6 publications

(1 citation statement)

References 44 publications

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“…In the same year, the Zhang group 105 devised another novel base-mediated synthesis of benzofuran heterocyclic cores. They carried out the transition-metal-free, potassium tert -butoxide-catalyzed synthesis of benzofuran derivatives 101 by treating substituted o -bromobenzylvinyl ketones 100 through intramolecular cyclization, using dimethylformamide as solvent.…”

Section: Precedented Approachesmentioning

confidence: 99%

A Comprehensive Review on Benzofuran Synthesis Featuring Innovative and Catalytic Strategies

Mushtaq,

Zahoor,

Ahmad

et al. 2024

ACS Omega

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Benzofurans have intrigued both pharmaceutical researchers and chemists owing to the medicinal usage of their derivatives against copious diseasecausing agents (i.e., bacteria, viruses, and tumors). These heterocyclic scaffolds are pervasively encountered in a number of natural products and drugs. The everincreasing utilization of benzofuran derivatives as pharmaceutical agents persuaded the chemists to devise novel and facile methodological approaches to assemble the biologically potent benzofuran nucleus. This review summarizes the current developments regarding the innovative synthetic routes and catalytic strategies to procure the synthesis of benzofuran heterocycles with their corresponding mechanistic details, reported by several research groups during 2021−2023.

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Section: Precedented Approachesmentioning

confidence: 99%