A novel bacterium-like particles platform displaying antigens by new anchoring proteins induces efficacious immune responses
Lingdi Niu,
Mingchun Gao,
Hongkun Ren
et al.
Abstract:Bacterium-like particles (BLP) are the peptidoglycan skeleton particles of lactic acid bacteria, which have high safety, mucosal delivery efficiency, and adjuvant effect. It has been widely used in recent years in the development of vaccines. Existing anchoring proteins for BLP surfaces are few in number, so screening and characterization of new anchoring proteins are necessary. In this research, we created the OACD (C-terminal domain of Escherichia coli outer membrane protein A) to serve as an anchoring prote… Show more
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