2022
DOI: 10.1101/2022.01.27.477972
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

A novel bacteriocin produced byBifidobacterium longumsubsp.infantishas dual antimicrobial and immunomodulatory activity

Abstract: Bacteriocins are ribosomally-synthesized antimicrobial peptides produced by bacteria with either narrow or broad spectrum activity. Many genome mining studies have indicated that bacteriocin gene clusters are widespread within certain gut microbiota members. In early life, Bifidobacterium comprise the dominant microbiota genus in vaginally delivered and breast-fed infants, with high levels associated with improved health. However, in many cases the mechanisms underlying these beneficial effects are unknown, al… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
4
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(4 citation statements)
references
References 54 publications
0
4
0
Order By: Relevance
“…It is also known that Bifidobacterium strains have antibacterial activity against various pathogens, including Escherichia coli, Streptococcus spp., Salmonella spp., Listeria spp. and Cutibacterium spp, 42 as well as against multidrug-resistant pathogens, 43 by nutrient competition, 44 biofilm removal or inhibition, 45 , 46 production of antimicrobial substances, 47 , 48 acidification, and enhancement of mucus barrier function. 49 In addition, Bifidobacterium can influence the overall composition and diversity of the gut microbiota, which helps to maintain a diverse and stable microbial community in the gut.…”
Section: Discussionmentioning
confidence: 99%
“…It is also known that Bifidobacterium strains have antibacterial activity against various pathogens, including Escherichia coli, Streptococcus spp., Salmonella spp., Listeria spp. and Cutibacterium spp, 42 as well as against multidrug-resistant pathogens, 43 by nutrient competition, 44 biofilm removal or inhibition, 45 , 46 production of antimicrobial substances, 47 , 48 acidification, and enhancement of mucus barrier function. 49 In addition, Bifidobacterium can influence the overall composition and diversity of the gut microbiota, which helps to maintain a diverse and stable microbial community in the gut.…”
Section: Discussionmentioning
confidence: 99%
“…The analysis of environmentally diverse bacteriocins implied class II bacteriocins' potential to interact closely with community members in the host. They may also be utilized to interact with the host itself, particularly in the case of human hosts (18).…”
Section: Class II Bacteriocins Exhibit Niche-specific Enrichment In H...mentioning
confidence: 99%
“…Another case showed the immunomodulatory activity of a lactococcin 972-like class IId bacteriocin from infant gut-derived Bifidobacterium longum subsp. infantis (18). Given that the human microbiome contains 150 times more genes than the human genome (19), class II bacteriocins within the human microbiome represent an untapped treasure for antimicrobial discovery and play a crucial role in mediating human health.…”
Section: Introductionmentioning
confidence: 99%
“…Colonization resistance is also aided by the production of toxic antimicrobial peptides by commensals. For example, many members of the phylum Bacteroidetes produce toxic antimicrobial peptides through their type 6 secretion systems (T6SS)[ 16 ], E. coli produces narrow-spectrum antibiotics called microcins that effectively kill competitors within their niche[ 17 , 18 ], and the probiotic Bifidobacterium secretes broad-spectrum bacteriocins[ 19 ].…”
Section: Gut Microbial Eubiosismentioning
confidence: 99%