A Novel Bacterial Pathogen of Biomphalaria glabrata: A Potential Weapon for Schistosomiasis Control?

Duval, David Timothy; Galinier, Richard; Mouahid, Gabriel; Toulza, Ève; Allienne, Jean‐François; Portela, Julien; Calvayrac, Christophe; Rognon, Anne; Arancibia, Nathalie; Mitta, Guillaume; Thèron, André; Gourbal, Benjamin

doi:10.1371/journal.pntd.0003489

Cited by 37 publications

(29 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This microbiome could also be involved in snail defense either directly by controlling pathogens or indirectly by stimulating the snail immune system or competing with pathogens. Snails are susceptible to pathogens ranging from bacteria [54] to multicellular parasites [55] such as schistosomes causing damages to the snail organs.…”

Section: Discussionmentioning

confidence: 99%

The hemolymph ofBiomphalariasnail vectors of schistosomiasis supports a diverse microbiome

Chevalier

Diaz

McDew-White

et al. 2020

Preprint

View full text Add to dashboard Cite

The microbiome – the microorganism community that is found on or within an organism’s body – is increasingly recognized to shape many aspects of its host biology and is a key determinant of health and disease. Microbiomes modulate the capacity of insect disease vectors (mosquitos, tsetse flies, sandflies) to transmit parasites and disease. We investigate the diversity and abundance of microorganisms within the hemolymph (i.e. blood) of Biomphalaria snails, the intermediate host for Schistosoma mansoni, using Illumina MiSeq sequencing of the bacterial 16S V4 rDNA. We sampled hemolymph from 5 snails from 6 different laboratory populations of B. glabrata and one population of B. alexandrina. We observed 281.34 ± 0.81 amplicon sequence variants (ASVs) per snail. There were significant differences in microbiome composition at the level of individual snails, snail populations and species. Snail microbiomes were dominated by Proteobacteria and Bacteroidetes while water microbiomes from snail tank were dominated by Actinobacteria. We investigated the absolute bacterial load using qPCR: hemolymph samples contained 2,620 ± 321 bacteria per μL. We speculate that the microbiome may represent a critical, but unexplored intermediary in the snail-schistosome interaction as hemolymph is in very close contact to the parasite at each step of its development.

show abstract

Section: Discussionmentioning

confidence: 99%

The hemolymph ofBiomphalariasnail vectors of schistosomiasis supports a diverse microbiome

Chevalier

Diaz

McDew-White

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, infected snails produce infected eggs causing decreased levels of hatching. These findings hold promise for P. glabratella as a potential biocontrol agent against the tropical parasitic disease Schistosomiasis which commonly uses these snails as vectors [162]. This has implications in developing countries where parasites are a significant cause of death.…”

Section: Pathogenicitymentioning

confidence: 99%

Current knowledge and perspectives of Paenibacillus: a review

et al. 2016

View full text Add to dashboard Cite

Isolated from a wide range of sources, the genus Paenibacillus comprises bacterial species relevant to humans, animals, plants, and the environment. Many Paenibacillus species can promote crop growth directly via biological nitrogen fixation, phosphate solubilization, production of the phytohormone indole-3-acetic acid (IAA), and release of siderophores that enable iron acquisition. They can also offer protection against insect herbivores and phytopathogens, including bacteria, fungi, nematodes, and viruses. This is accomplished by the production of a variety of antimicrobials and insecticides, and by triggering a hypersensitive defensive response of the plant, known as induced systemic resistance (ISR). Paenibacillus-derived antimicrobials also have applications in medicine, including polymyxins and fusaricidins, which are nonribosomal lipopeptides first isolated from strains of Paenibacillus polymyxa. Other useful molecules include exo-polysaccharides (EPS) and enzymes such as amylases, cellulases, hemicellulases, lipases, pectinases, oxygenases, dehydrogenases, lignin-modifying enzymes, and mutanases, which may have applications for detergents, food and feed, textiles, paper, biofuel, and healthcare. On the negative side, Paenibacillus larvae is the causative agent of American Foulbrood, a lethal disease of honeybees, while a variety of species are opportunistic infectors of humans, and others cause spoilage of pasteurized dairy products. This broad review summarizes the major positive and negative impacts of Paenibacillus: its realised and prospective contributions to agriculture, medicine, process manufacturing, and bioremediation, as well as its impacts due to pathogenicity and food spoilage. This review also includes detailed information in Additional files 1, 2, 3 for major known Paenibacillus species with their locations of isolation, genome sequencing projects, patents, and industrially significant compounds and enzymes. Paenibacillus will, over time, play increasingly important roles in sustainable agriculture and industrial biotechnology.Electronic supplementary materialThe online version of this article (doi:10.1186/s12934-016-0603-7) contains supplementary material, which is available to authorized users.

show abstract

“…The bacterial pathogen, Paenibacillus glabratella, recently discovered by Duval et al [74] has been observed to infect and cause high mortality in snails, therefore, making a promising BCA for the control of snails.…”

Section: Bacteriamentioning

confidence: 99%

Biological Control of Parasites

Kwenti¹

2017

Natural Remedies in the Fight Against Parasites

View full text Add to dashboard Cite

Parasites (ectoparasites or endoparasites) are a major cause of diseases in man, his livestock and crops, leading to poor yield and great economic loss. To overcome some of the major limitations of chemical control methods such as rising resistance, environmental and health risks, and the adverse effect on non-target organisms, biological control (biocontrol) is now at the forefront of parasite (pests) control. Biocontrol is now a core component of the integrated pest management. Biocontrol is defined as "the study and uses of parasites, predators and pathogens for the regulation of host (pest) densities". Considerable successes have been achieved in the implementation of biocontrol strategies in the past. This chapter presents a review of the history of biocontrol, its advantages and disadvantages; the different types of biological control agents (BCAs) including predators, parasites (parasitoids) and pathogens (fungi, bacteria, viruses and virus-like particles, protozoa and nematodes); the effect of biocontrol on native biodiversity; a few case studies of the successful implementation of biocontrol methods and the challenges encountered with the implementation of biocontrol and future perspectives.

show abstract

A Novel Bacterial Pathogen of Biomphalaria glabrata: A Potential Weapon for Schistosomiasis Control?

Cited by 37 publications

References 94 publications

The hemolymph ofBiomphalariasnail vectors of schistosomiasis supports a diverse microbiome

The hemolymph ofBiomphalariasnail vectors of schistosomiasis supports a diverse microbiome

Current knowledge and perspectives of Paenibacillus: a review

Biological Control of Parasites

Contact Info

Product

Resources

About