A Novel Auraptene-Enriched Citrus Peels-Based Blend with Enhanced Antioxidant Activity

Fiorito, Serena; Epifano, Francesco; Palumbo, Lucia; Genovese, Salvatore

doi:10.1007/s11130-021-00911-w

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…This seems to greatly facilitate the adsorption and consequently the interaction with organic compounds, like gentiopicroside ( 1 ) and amarogentin ( 2 ), presumably due to interactions of a lipophilic nature or of the van der Waals type. The present results confirm a trend exhibited by these same materials (especially by Mg Al azelate, entry E) with other classes of natural products like anthraquinones, phenolic acids, flavonoids, purine alkaloids, diarylheptanoids, capsaicinoids, oxyprenylated coumarins, apocarotenoids, and anthocyanins …”

supporting

confidence: 88%

Leaves of Yellow Gentian (Gentiana lutea) as an Alternative Source of Bitter Secoiridoid Glycosides

et al. 2022

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In a search for methods of manufacturing bitter principles from Gentiana lutea, mainly represented by gentiopicroside (1) and amarogentin (2), as an alternative to extraction from the roots of this plant, in this short communication it is shown that the leaves of this plant can be regarded as an additional source of such phytochemicals. Extraction of G. lutea leaves was coupled to solid-phase adsorption by differently structured solids as a separation technology step, providing a selective isolation of both these secondary metabolites in good to excellent yields. Thus, the extraction of bitter secoiridoids can be achieved in an equivalent or improved way rather than processing the roots of G. lutea while preserving the biodiversity of the species.

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supporting

confidence: 88%

Leaves of Yellow Gentian (Gentiana lutea) as an Alternative Source of Bitter Secoiridoid Glycosides

et al. 2022

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“…AUR, a well-known coumarin is well known as an outstanding antioxidant with radical scavenger activities. Antioxidative activity of AUR is higher than reference substances (Ascorbic acid and Trolox ® ) [4]. AUR with antioxidant activities has been acknowledged in several studies using other experimental models [26].…”

Section: Discussionmentioning

confidence: 99%

“…Auraptene (7-geranyloxycoumarin, AUR) is a natural bioactive coumarin derivative that can be isolated from citrus fruits [1]. In a recent study, it has been shown that AUR has a variety of pharmacological actions, including antioxidative, anti-inflammatory, anticancer, neuroprotective, and immunomodulatory properties [2][3][4][5][6]. Additionally, there was no significant difference in acute and subacute toxic histopathological effects and immunotoxicity evaluation in rats [7].…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Auraptene Improves Aged Oocyte Quality and Embryo Development in Mice

et al. 2022

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Decrease in quality of postovulatory aged oocytes occurs due to oxidative stress and leads to low fertilization and development competence. It is one of the main causes that exerting detrimental effect on the success rate in assisted reproductive technology (ART). Auraptene (AUR), a citrus coumarin, has been reported to possess an antioxidant effects in other tissues. In this study, we aimed to confirm the potential of AUR to delay the oocyte aging process by alleviating oxidative stress. Superovulated mouse oocytes in metaphase of second meiosis (MII) were exposed to 0, 1 or 10 μM AUR for 12 h of in vitro aging. AUR addition to the culture medium recovered abnormal spindle and chromosome morphology and mitigated mitochondrial distribution and mitochondrial membrane potential (ΔΨ) in aged oocytes. AUR-treated aged oocytes also showed suppressed oxidative stress, with lower reactive oxygen species (ROS) levels, higher glutathione (GSH) levels and increased expression of several genes involved in antioxidation. Furthermore, AUR significantly elevated the fertilization and embryo developmental rates. Oocytes aged with 1 μM AUR exhibited morphokinetics that were very similar to those of the control group. Altogether, these data allowed us to conclude that AUR improved the quality of aged oocytes and suggest AUR as an effective clinical supplement candidate to prevent postovulatory aging.

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“…37 LDHs are ideally biocompatible and have several industrial applications to produce a plethora of cosmetic, nutraceutical, and pharmaceutical preparations. 38 During the last three years, lamellar solids have found extensive use in phytochemistry and have been shown to be tremendously efficient for the selective extraction of classes of plant secondary metabolites like flavonoids, catechins, alkaloids, 39 diarylheptanoids, 40 bitter secoiridoids, 41,42 capsaicinoids, 43 oxyprenylated coumarins, 44 tetraterpenes, 45 and anthocyans. 46 48 The pattern of adsorption was practically the same, allowing good to excellent recovery of anthraquinones (all or some) by using the same two sorbents mentioned above in addition to magnesium aluminum azelate, which also displayed good performance.…”

Section: Lamellar Solidsmentioning

confidence: 99%

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Palumbo

Fiorito

Epifano

et al. 2023

Phytochemical Analysis

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Introduction: Solid-phase extraction applied to plant matrices is nowadays a wellvalidated technique allowing to concentrate and purify different secondary metabolites. Several classes of phytochemicals have been selectively extracted by this methodology. During the last decade attention has been focused on biologically active anthraquinones from numerous sources like edible, healthy, and medicinal plants. Objectives: The aim of this review is to provide a detailed literature survey of the solid-phase adsorption methodologies for the extraction of natural anthraquinones reported so far and to discuss and propose future directions in this field of research. Materials and Methods: Substructure search was performed in the SciFinder Scholar, PubMed, Medline, and Scopus databases. Results: The first report about application of solid-phase adsorption for the purification of anthraquinones appeared in the literature in 2002. From this date, and in particular during recent years, the most notable examples included the use of chitin-and chitosan-based polymers, of molecularly imprinted polymers, of coated magnetic nanoparticles, of miniaturized matrix solid-phase dispersion, of functionalized resins, of differently structured lamellar solids, and finally of vortex-synchronized matrix solid-phase dispersion. Conclusions:The herein detailed solid-phase adsorption methodologies are powerful tools to selectively extract natural anthraquinones and/or provide anthraquinoneenriched phytopreparations. Nevertheless, many other important methods have been applied to synthetic anthraquinones (e.g., azo dyes). These could be conveniently employed also for natural anthranoids. Studies in this field are discussed in this review article.

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A Novel Auraptene-Enriched Citrus Peels-Based Blend with Enhanced Antioxidant Activity

Cited by 7 publications

References 3 publications

Leaves of Yellow Gentian (Gentiana lutea) as an Alternative Source of Bitter Secoiridoid Glycosides

Leaves of Yellow Gentian (Gentiana lutea) as an Alternative Source of Bitter Secoiridoid Glycosides

The Antioxidant Auraptene Improves Aged Oocyte Quality and Embryo Development in Mice

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

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