A Novel Association Between Polycystic Ovary Syndrome and Helicobacter pylori

Yavaşoğlu, İrfan; Arslan, Erol; Küçük, Mert; Cildag, Burak; Gök, Mehmet Ali; Kafkas, Samet

doi:10.1097/maj.0b013e3181a63c8a

Cited by 21 publications

(26 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No statistically significant difference was seen between the two groups, PCOS women and non-PCOS women with their spouses. Moreover, Yavasoglu reported the percentage of positive IgG titers in 60% of women with PCOS and 40% of women without PCOS (2). Due to the lack of a significant statistical association between positive cases IgG antibodies against H. pylori in the two groups in this study, there is no statistically significant association between Iranian men and women; perhaps there is a higher rate of H. pylori infection.…”

Section: Discussioncontrasting

confidence: 48%

“…In association with PCOS and H. pylori infection, Yavasoglu conducted the first study on 35 men and 50 women with non-PCOS and PCOS groups with evaluation of antibodies IgG. In this study, the positive IgG at female cases with PCOS was 40% and in control group was 22%,which showed a significant difference (2). In a study of Jafarzadeh et al (17), 386 children aged 1 -15 years and 200 adults aged 20 -60 years were investigated in specific serum immunoglobulin G to H. pylori and CagA.…”

Section: Discussionmentioning

confidence: 84%

“…In the recent years, studies have shown the role of Helicobacter pylori in the development of endocrinopathies. Yavasoglu et al reported a raised incidence of H. pylori seropositivity in women with PCOS (2). Helicobacter pylori infection affects more than half of the world's people and is most commonly associated with chronic gastritis which afterward increases the risk of many serious complications including gastric cancer (3).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serological Diagnosis of Helicobacter pylori Infection in Patients With a Polycystic Ovary Syndrome

Kiani

Asadbeik

Hasannejad‐Bibalan

et al. 2015

Arch Clin Infect Dis

View full text Add to dashboard Cite

Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in 4% -6% of women in the reproductive age and is a common cause of infertility. Even though the number of investigations is scarce, studies show that Helicobacter pylori infection may influence reproduction. Objectives: The purpose of this study was to determine and compare the levels of H. pylori specific antibodies IgA, IgG and anti-CagA at both PCOS and non-PCOS women with their spouses using the serological test. Patients and Methods:In this cross-sectional study, 127 women with their spouses (age range, 30 -60 years) were selected. These patient were referred to infertility center of Shariati Hospital in Tehran, Iran, with a diagnostic criteria of PCOS based on Androgen Excess Society (AES). The specific antibodies of IgA, IgG and anti-CagA were measured using the commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit. Results: The positive titers of H. pylori antibodies IgA, IgG and anti-CagA in the PCOS group were 45 (35%), 79 (62%) and 77 (60.5%), respectively, while in non-PCOS group were 38 (30%), 76 (60%) and 50 (39.5%), respectively. The sera positive for IgA, IgG and anti-CagA antibodies in spouses of the non-PCOS group were 38 (30%), 84 (66%) and 79 (62%) respectively, but in spouses of the PCOS group were 51 (40%), 83 (66%) and 48 (38%), respectively. The results showed that H. pylori infection probably did not affect infertility or reproduction. Conclusions:Findings of this study demonstrate no significant difference between levels of H. pylori specific antibodies of IgA, IgG, anti-CagA and the presence of PCOS disorders, and also indicate that serologic testing is a sensitive method for the detection of H. pylori antibodies. The high prevalence of H. pylori positive antibody levels in both PCOS and non-PCOS patients can be probably associated with the high frequency of H. pylori infection.

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serological Diagnosis of Helicobacter pylori Infection in Patients With a Polycystic Ovary Syndrome

Kiani

Asadbeik

Hasannejad‐Bibalan

et al. 2015

Arch Clin Infect Dis

View full text Add to dashboard Cite

show abstract

“…The simultaneous presence of elevated hs-CRP levels strengthened this association. In another study, seropositivity to Helicobacter pylori was significantly more common among women with PCOS than in an age-matched control group (56). Most recently, a study evaluating markers of periodontal disease compared 25 non-obese women with PCOS with 27 age and weight-matched control women (57).…”

Section: Views In Favor Of Inflammation-- Antoni J Duleba MDmentioning

confidence: 96%

“…Indeed, a recent large, prospective study evaluating over 10,000 participants verified the relationship between periodontal disease and cardiovascular mortality (54). Literature evaluating the role of pathogens in PCOS is still minimal but suggests a possible association of this syndrome with Chlamydia species, Helicobacter pylori and periodontal disease (55,56,57). Specifically, seropositivity to Chlamydia pneumonia and Chlamydia trachomatis was significantly greater among women with self-reported oligomenorrhea and hirsutism than in control subjects (55).…”

Section: Views In Favor Of Inflammation-- Antoni J Duleba MDmentioning

confidence: 99%

Is PCOS an inflammatory process?

Dulęba

Dokras

2012

Fertility and Sterility

247

159

View full text Add to dashboard Cite

PRO-- PCOS is associated with low-grade systemic inflammation as evidenced by elevation of multiple markers of inflammation such as C-reactive protein, interleukin-18, monocyte chemoattractant protein-1 and white blood count as well as endothelial dysfunction and increased oxidative stress. CON-- The evidence in support of the presence of chronic inflammatory state in the majority of women with PCOS is incontrovertible. It is apparent that PCOS is associated with a significant elevation of multiple markers of inflammation including CRP, IL-18, MCP-1, and white blood count. Furthermore, PCOS is associated with other derangements associated with inflammation such as increased oxidative stress and endothelial dysfunction. While the etiology of systemic inflammation in PCOS remains unclear, recent data raise the intriguing possibility of a link between PCOS, inflammation and chronic low grade infectious agents such as Chlamydia pneumoniae, Helicobacter pylori and pathogens inducing periodontal inflammation.

show abstract

High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients

Wang

Peng

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is one of the most prevalent reproductive disorders in women worldwide. Despite rigorous research, the exact molecular mechanism that governs PCOS pathogenesis remains unclear. To investigate the potential roles of circular RNAs (circRNAs), this study sequenced ribosomal RNA‐depleted total RNA from exosomes of follicle fluids obtained from PCOS patients using non‐PCOS samples as controls. Bioinformatic analysis identified 167 upregulated and 245 downregulated circRNAs from a total of 16,771 detected candidates. Functional analysis suggests that pathways related to bacterial infection, associated chronic inflammation, and oxidative stress could be targeted by the differential circRNAs in PCOS patients. The obtained sequencing results were further validated by quantitative reverse‐transcription polymerase chain reaction and a circRNA–microRNA interaction network was constructed. The obtained results provide a valuable addition to the published studies on the mechanism of PCOS pathogenesis by revealing a wide variety of new circRNAs, miRNA, and gene targets that merit further investigation.

show abstract

A Novel Association Between Polycystic Ovary Syndrome and Helicobacter pylori

Cited by 21 publications

References 23 publications

Serological Diagnosis of Helicobacter pylori Infection in Patients With a Polycystic Ovary Syndrome

Serological Diagnosis of Helicobacter pylori Infection in Patients With a Polycystic Ovary Syndrome

Is PCOS an inflammatory process?

High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients

Contact Info

Product

Resources

About