A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs

Farjadian, Fatemeh; Azadi, Soha; Mohammadi-Samani, Soliman; Ashrafi, Hajar; Azadi, Amir

doi:10.1016/j.heliyon.2018.e00930

Cited by 15 publications

(6 citation statements)

References 38 publications

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“…The effects of MS on a wide range xenobiotics, namely heavy metals, acetaminophen, phenobarbital, and iron and copper overload has been successfully tested by our research team. 18 , 52 …”

Section: Discussionmentioning

confidence: 99%

“…The effects of MS on a wide range xenobiotics, namely heavy metals, acetaminophen, phenobarbital, and iron and copper overload has been successfully tested by our research team. 18,52 The current investigation was designed to synthesize a functionalized MS for ammonium ion adsorption in vitro and alleviating HE as a severe clinical complication in an animal model. We found that MS has mainly remained in the GI (Figure 8).…”

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confidence: 99%

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<p>In vitro and in vivo Evaluation of Succinic Acid-Substituted Mesoporous Silica for Ammonia Adsorption: Potential Application in the Management of Hepatic Encephalopathy</p>

Mohammadi¹,

Heidari²,

Niknezhad³

et al. 2020

IJN

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Purpose Hepatic encephalopathy (HE) is a critical situation in which liver failure affects brain function. HE could result in a state of coma and death. The liver is the main organ for ammonium ion (NH 4 + ) metabolism. Hence, acute and/or chronic liver failure could lead to hyperammonemia. NH 4 + is the most suspected neurotoxic agent in HE. Thus, finding new therapeutic options to decrease plasma and brain NH 4 + levels has a significant clinical value. Mesoporous silica (MS) particles have revolutionized many aspects of pharmaceutical sciences, including drug delivery systems. Moreover, recently, MS has been applied as agents for the detoxification of chemicals (eg, drugs and poisons). Methods First, MS particles containing amine groups (MS-NH 2 ) were synthesized in co-condensation processes. Then, the structure was modified by succinic anhydride to have MS-SA. The MS-SA was characterized (FT-IR, XRD, X-ray photoelectron spectroscopy (XPS), DLS-Zeta FESEM-EDX, and HRTEM). Then, the potential of MS-NH 2 and MS-SA particles in adsorption of NH 4 + was investigated in vitro and in vivo. MS-NH 2 and MS-SA were incubated with increasing concentrations (0.1–10 mM) of NH 4 + , and the scavenging capacity of the investigated particles was evaluated. On the other hand, different doses (1 and 5 mg/kg per day) of nanoparticles were administered to a hyperammonemia animal model. Results It was figured out that both MS-NH 2 and MS-SA significantly scavenged NH 4 + in the in vitro model. However, the NH 4 + scavenging capability of MS-SA was more significant. Administration of MS-NH 2 and MS-SA also considerably decreased the level of ammonium in plasma and brain and improved cognitive and locomotor activity in hyperammonemic animals. The effects of MS-SA were more significant than MS-NH 2 in the HE animal model. Conclusion Collectively, our data suggest that MS particles, especially succinic acid-functionalized MS, could act as special ancillary treatment in HE as a critical clinical complication.

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“…The effects of MS on a wide range xenobiotics, namely heavy metals, acetaminophen, phenobarbital, and iron and copper overload has been successfully tested by our research team. 18 , 52 …”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

<p>In vitro and in vivo Evaluation of Succinic Acid-Substituted Mesoporous Silica for Ammonia Adsorption: Potential Application in the Management of Hepatic Encephalopathy</p>

Mohammadi¹,

Heidari²,

Niknezhad³

et al. 2020

IJN

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“…Another possible way of utilization is the formation of specific systems for drug delivery [19]. Otherwise, the HCP structures have found a great use in macro-, micro-, and nano-applications in electronics [20], electro-optics [21,22], bioanalytics [23], or in nanofabrication [24].…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility of Polymethyl Methacrylate Honeycomb-like Pattern on Perfluorinated Polymer

et al. 2021

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In this study, we present a simple approach for developing a biocompatible polymer scaffold with a honeycomb-like micropattern. We aimed to combine a plasma treatment of fluorinated ethylene propylene (FEP) substrate with an improved phase separation technique. The plasma exposure served for modification of the polymer surface properties, such as roughness, surface chemistry, and wettability. The treated FEP substrate was applied for the growth of a honeycomb-like pattern from a solution of polymethyl methacrylate (PMMA). The properties of the pattern were strongly dependent on the conditions of plasma exposure of the FEP substrate. The physico-chemical properties of the prepared pattern, such as changes in wettability, aging, morphology, and surface chemistry, were determined. Further, we have examined the cellular response of human osteoblasts (U-2 OS) on the modified substrates. The micropattern prepared with a selected combination of surface activation and amount of PMMA for honeycomb construction showed a positive effect on U-2 OS cell adhesion and proliferation. Samples with higher PMMA content (3 and 4 g) formed more periodic hexagonal structures on the surface compared to its lower amount (1 and 2 g), which led to a significant increase in the pattern cytocompatibility compared to pristine or plasma-treated FEP.

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“…To address these questions, we have studied three models of functionalized mesoporous silica particles (MS-NH 2 , MS-3NH 2 , and MS-chitosan), varying according to their electrostatic and hydrophobic moieties, on fibrillation of human insulin. Of all the mesoporous materials (particles having a uniform pore size between 2 and 50 nm), mesoporous silica particles, due to their uniform pore size, highly ordered structure, and functionalizability, are of particular interest in industrial and academic communities as drug delivery systems. − Currently, new applications of these particles are being introduced. ,− …”

Section: Introductionmentioning

confidence: 99%

Mechanistic Assessment of Functionalized Mesoporous Silica-Mediated Insulin Fibrillation

et al. 2020

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Insulin, which is a small protein hormone consisting of 51 amino acids, rapidly fibrillates under stressogenic conditions. This biotechnological/ medical problematic reaction quickly accelerates in the presence of some particles, while there are several other particles that slow down the kinetic process. To address the unexplored demand of the particles that modulate protein fibrillation, we have synthesized two amino-based particles and a chitosan-coated mesoporous silica particle (MS-NH 2 , MS-3NH 2 , and MS-chitosan) to investigate insulin fibrillation. While these particles were fairly similar in size, they are differ in their net positive charge and surface hydrophobicity. To monitor the exact role of the hydrophobic interaction between the protein and MS-chitosan during the fibrillation, we have also co-and preincubated insulin with cholesterol and the particles under stressogenic conditions. The results indicate that MS-NH 2 and MS-3NH 2 , due to their high positive charges and lack of surface hydrophobicity, repel the positively charged unfolded insulins at pH 2.0. Moreover, MS-chitosan with 25% surface hydrophobicity stacks partially unfolded insulins to its surface and induces some α-helix to β-sheet structural transitions to the protein. Consequently, both amino-and chitosan-based particles slow down the kinetics of the fibrillation. We also showed that cholesterol can structurally participate in insulin fibril architecture as a hydrophobic bridge, and extraction of this molecule from the preformed fibrils may disrupt the fibril structure.

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A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs

Cited by 15 publications

References 38 publications

<p>In vitro and in vivo Evaluation of Succinic Acid-Substituted Mesoporous Silica for Ammonia Adsorption: Potential Application in the Management of Hepatic Encephalopathy</p>

<p>In vitro and in vivo Evaluation of Succinic Acid-Substituted Mesoporous Silica for Ammonia Adsorption: Potential Application in the Management of Hepatic Encephalopathy</p>

Cytocompatibility of Polymethyl Methacrylate Honeycomb-like Pattern on Perfluorinated Polymer

Mechanistic Assessment of Functionalized Mesoporous Silica-Mediated Insulin Fibrillation

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