A novel approach to Morita–Baylis–Hillman (MBH) lactones via the Lewis acid-promoted couplings of α,β-unsaturated lactone with aldehydes

Recent Contributions from the Baylis−Hillman Reaction to Organic Chemistry

“…Guo et al 113 have also employed acrylamide and The coupling of pyrandihydro-5H-2-one (1) with various aldehydes has been conveniently performed by Li and coworkers in the presence of diethylaluminum iodide to provide the resulting Baylis-Hillman adducts in high yields (eq 2). 75 1-Benzopyran-4(4H)-one derivatives have been systematically used as novel activated alkenes in the Baylis-Hillman coupling with reactive electrophiles such as heteroaromatic aldehydes, nitrobenzaldehydes, and isatin derivatives by our research group (Scheme 2). 114 The Baylis-Hillman adducts thus derived from pyridine-2-carboxaldehyde as electrophile were converted into the novel tetracyclic indolizine-fused chromone frameworks (Scheme 2).…”

“…The coupling of pyrandihydro-5 H -2-one ( 1 ) with various aldehydes has been conveniently performed by Li and co-workers in the presence of diethylaluminum iodide to provide the resulting Baylis−Hillman adducts in high yields (eq ) …”

"Synthesis of 2-Amino-3-Phenylpropan-1-Ol Compounds From Baylis-Hillman Derivatives, Carbon Nanotube, Kinetic, Lifetime and Biological Studies "

“…Many variations of parameters present in this reaction, in fact, generate wide spectra of mechanistic pathways, thereby making understanding the mechanism of this reaction an intellectual challenge. The Baylis-Hillman adducts have been successfully utilized as synthons in several named reactions such as Heck reaction, Diels-Alder reaction, Aldol condensation, Claisen rearrangement, Friedel-Crafts reation [7][8][9][10] etc. The FriedelCraftsreaction is one of the most widely used reactions in organic chemistry whose applications in academic as well as industrial fields have been well documented.…”