A novel approach to improve detection of glucocorticoid doping in sport with new guidance for physicians prescribing for athletes

Ventura, Rosa; Daley‐Yates, Peter T.; Mazzoni, Irene; Collomp, K.; Saugy, Martial; Buttgereit, Frank; Rabin, Olivier; Stuart, Mark

doi:10.1136/bjsports-2020-103512

Cited by 19 publications

(13 citation statements)

References 69 publications

(70 reference statements)

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“…Sports dance is an emerging sport with strong technical and artistic qualities; it integrates art, sports, music, and dance, and it is called a model of the combination of “health” and “beauty” [ 1 ]. While the male and female players showed vigorous sports movements, it is also necessary to show the attractive artistic beauty of dance movements.…”

Section: Introductionmentioning

confidence: 99%

MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers

Yang

2022

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In order to solve the problem of the difference in the diagnostic effect of different sequences of magnetic resonance imaging (MRI) examinations for anterior and posterior cruciate ligament injuries, the author proposes an MRI rehabilitation method to relieve anterior cruciate ligament injury in dancers. This method retrospectively analyzed the clinical data of 60 patients with knee anterior and posterior cruciate ligament injuries in our hospital, and all patients were diagnosed with knee anterior and posterior cruciate ligament injuries. All patients underwent MRI 3D sequence and 2D sequence examination successively to compare anatomical measurements. This study aimed at comparing the measurements of the posterior cruciate ligament (PCL) and anterior cruciate ligament (ACL) between the two examination sequences; comparing the diagnosis; comparing the grading and judgment of the anterior and posterior cruciate ligament injuries of the knee joint between the two inspection sequences; and comparing the diagnostic coincidence rates of the two examination sequences in the complete tear of the anterior and posterior cruciate ligaments of the knee. Experimental results show that, in terms of PCL and ACL, the angle, thickness, and length of two-dimensional MRI examination were significantly different from those of MRI examination and anatomical measurement ( P < 0.05 ); for PCL and ACL, the angle, thickness, and length of 3D MRI were not significantly different from anatomical measurements ( P > 0.05 ). The diagnostic accuracy of 2D MRI was 83.33%, which was lower than 95.00% of 3D MRI ( P < 0.05 ). There was no significant difference in the grading of anterior and posterior cruciate ligament injuries between the two examination sequences ( P > 0.05 ). The diagnostic coincidence rates of 3D MRI and 2D MRI for complete tear of the anterior and posterior cruciate ligaments were 95.55% and 80.00%, respectively ( P < 0.05 ). In conclusion, three-dimensional MRI examination can obtain higher diagnostic value for patients with knee joint anterior and posterior cruciate ligament injury.

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Section: Introductionmentioning

confidence: 99%

MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers

Yang

2022

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“…17 19-22 In addition, a recent review of the literature showed a urinary detection period of triamcinolone acetonide ranging from 3 to 8 days after the IA injection, in limited groups of up to eight people. 22 During the Olympic Games in Rio (2016), a register specially created to report on the therapeutic injections performed found that there was significant use of GC injections. 1 Medical doctors, sports and exercise physiologist and sports organisations experts (eg, Fédération Internationale de Football Association and International Cycling Union) have already reported on the excessive use of GC injections prior to competitions, a procedure which is not without consequences to health.…”

Section: Open Accessmentioning

confidence: 99%

SporTRIA study—a multicentre trial protocol for excretion kinetics of triamcinolone acetonide following sport-related intra-articular injections in knees: definitions of the washout periods

et al. 2021

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IntroductionIntra-articular (IA) and peri-articular glucocorticoid (GC) injections are common in sports medicine. However, from 1 January 2022, all injectable GC routes (including IA administration) will be prohibited in-competition by World Anti-Doping Agency (WADA). Owing to these rules, an IA GC treatment out-of-competition could result in an adverse analytical finding in-competition if the washout period is not clearly defined. The aim of this study is to determine the urinary excretion profile of triamcinolone acetonide following IA injection to strengthen the definition of the washout periods.Methods and analysisThis is a prospective multicentre trial to include 20 subjects who practice sports for at least 4 hours/week and present a knee disorder requiring IA injection of triamcinolone acetonide for therapeutic purposes. To determine the excretion profile of triamcinolone acetonide in both urine and blood following IA injection of the drug, We will perform 20 urinary tests and 20 dried blood spot tests, two prior to GC injection (baseline) and the last one at 35 days. Analyses will be performed by the French antidoping agency laboratory in accordance with WADA standards and regulations.Ethics and disseminationThe study protocol was approved by the French ethics committee (CPP Sud Est III—Lyon—2020-070B on 06 October 2020). All subjects will provide written informed consent. The results of this study will be accessible in peer-reviewed publication and be presented at academic conference.Trial registration numberNCT04574232.

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“…The novel approach by WADA under way to the 2022 List is the permission or prohibition of glucocorticoids in sport based on the pharmacological influence on performance enhancement and the risk of adverse effects on health. Substance-specific reporting limits are under introduction to the new version of MRPL TD to better distinguish prohibited and permitted use in sport [65].…”

Section: Minimum Required Performance Levels Tdmentioning

confidence: 99%

Olympic Anti-Doping Laboratory: The Analytical Technological Road From 2016 Rio De Janeiro to 2021 Tokyo

et al. 2021

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The summer Olympic Games is the major mega sports event since the first modern era Olympiad, held in Athens, Greece in 1896. International Olympic Committee (IOC) has the responsibility of the organization of the summer and winter Games ensuring the broadcast in all corners of earth. The World Anti-Doping Agency (WADA) is the responsible organization of the fight against doping in sports. IOC and WADA support the event's country WADA Accredited Laboratory to incorporate the maximum of the new analytical technologies to become applicable during the event's antidoping testing. The current study reviewed the last 5 years progresses of the antidoping system with emphasis on the laboratory field.

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A novel approach to improve detection of glucocorticoid doping in sport with new guidance for physicians prescribing for athletes

Cited by 19 publications

References 69 publications

MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers

MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers

SporTRIA study—a multicentre trial protocol for excretion kinetics of triamcinolone acetonide following sport-related intra-articular injections in knees: definitions of the washout periods

Olympic Anti-Doping Laboratory: The Analytical Technological Road From 2016 Rio De Janeiro to 2021 Tokyo

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