A novel approach to enhance the mucoadhesion of lipid drug nanocarriers for improved drug delivery to the buccal mucosa

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

“…Studies investigating stimuli responsiveness of lyotropic liquid crystalline nanostructured particles, such as inducing a stable vesicle to unstable cubosome transformation in situ as reported recently by Du et al, have highlighted the possibility of maintaining stable lyotropic liquid crystalline nanostructured particle dispersions in the absence of a stabilizer, by maintaining a specific pH (e.g., pH 8 in Du's study) [224]. Therefore, one of the future directions for maintaining stable lyotropic liquid crystalline nanostructured particle dispersions may depend on investigating different solvent conditions, such as temperature and pH.…”

Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules

“…Previous studies have shown that addition of 10% OA to phytantriol cubic phase will produce a system that switches from cubic phase to hexagonal phase upon decreasing the pH from 7.4 to 5.5 (Du et al, 2014). Hence this was the starting point for these investigations.…”

“…It has also been reported that for GMO-water systems, oleic acid (OA) played a significant role in altering the phase behaviour. OA affects the molecular packing of the lipid, such that when the head group is deprotonated, electrostatic repulsion induces the formation of larger water channels (Du et al, 2014;Salentinig et al, 2010).…”

“…Additionally, OA as an ionizable compound allows dynamic switching between H 2 and V 2 phases using pH (Du et al, 2014) and hence, has the potential to provide a mechanism to control drug release on demand. pH changes arise naturally within the human body, which makes this parameter an ideal stimulus (Kost and Langer, 2012;Langer, 1990;Negrini and Mezzenga, 2011).…”

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

“…[82][83][84][85] Mucoadhesion of thermosensitive gels and LCs can be explained by their rheological properties. 39,41,[86][87][88][89][90][91] Moreover, the mucoadhesive force of the liquid crystalline phases is determined by their ability to take up water from the environment. 87 Many theories have attempted to explain the biomucoadhesion; however, for the systems developed, the elastic behavior (G′.G″) has an influence on the bioadhesive process.…”