A novel approach to designing viral precision vaccines applied to SARS-CoV-2
Khaled Trabelsi,
Noureddin Ben Khalaf,
Ahmed R. Ramadan
et al.
Abstract:Efficient precision vaccines against several highly pathogenic zoonotic viruses are currently lacking. Proteolytic activation is instrumental for a number of these viruses to gain host-cell entry and develop infectivity. For SARS-CoV-2, this process is enhanced by the insertion of a furin cleavage site at the junction of the spike protein S1/S2 subunits upstream of the metalloprotease TMPRSS2 common proteolytic site. Here, we describe a new approach based on specific epitopes selection from the region involved… Show more
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