A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine

Karaman, Adem; Diyarbakir, Busra; Durur-Subasi, İrmak; Köse, Duygu; Bilgin, Asli Ozbek; Topçu, Atilla; Gündoğdu, Cemal; Karakaya, Afak Durur; Bayraktutan, Zafer; Alper, Fatih

doi:10.1259/bjr.20150716

Cited by 15 publications

(9 citation statements)

References 55 publications

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“…All of the studies demonstrated the renoprotective effect by attenuating serum Cr and renal histological damage through their antioxidant activities (Table 4). Both inflammatory process and apoptosis were decreased following antioxidant treatments [35][36][37][38][42][43][44]. Active component of herbs; such as astragaloside, [45] curcumin, [46] grape seed proanthocyanidin, [47] lycopene, [48] magnolin (major active ingredient of herb Magnolia fargesii), [49] Phyllanthus emblica extract, [50] salidroside, [40] sesame oil, [51] and silymarin, [52] were investigated in CIN in rats (Table 4).…”

Section: Antioxidants As Interventions To Reduce Cinmentioning

confidence: 99%

“…Many antioxidants; such as vitamin E, [ 35 ] L-carnitine, [ 36 ] human serum albumin-thioredoxin-1 fusion protein (HSA-Trx), [ 37 ] paricalcitol, [ 38 ] N-acetylcysteine (NAC), [ 39 , 40 ] recombinant manganese SOD (rMnSOD), [ 41 ] and agomelatine and melatonin; [ 42 – 44 ] were investigated for their potential effects to prevent CIN in rat models. All of the studies demonstrated the renoprotective effect by attenuating serum Cr and renal histological damage through their antioxidant activities (Table 4 ).…”

Section: Interventions Targeting Ros For Cin Prevention: Evidence Fromentioning

confidence: 99%

Section: Interventions Targeting Ros For Cin Prevention: Evidence Fromentioning

confidence: 99%

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Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Kusirisin

Chattipakorn

2020

J Transl Med

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Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an iatrogenic acute kidney injury observed after intravascular administration of contrast media for intravascular diagnostic procedures or therapeutic angiographic intervention. High risk patients including those with chronic kidney disease (CKD), diabetes mellitus with impaired renal function, congestive heart failure, intraarterial intervention, higher volume of contrast, volume depletion, old age, multiple myeloma, hypertension, and hyperuricemia had increased prevalence of CIN. Although CIN is reversible by itself, some patients suffer this condition without renal recovery leading to CKD or even end-stage renal disease which required long term renal replacement therapy. In addition, both CIN and CKD have been associated with increasing of mortality. Three pathophysiological mechanisms have been proposed including direct tubular toxicity, intrarenal vasoconstriction, and excessive production of reactive oxygen species (ROS), all of which lead to impaired renal function. Reports from basic and clinical studies showing potential preventive strategies for CIN pathophysiology including low- or iso-osmolar contrast media are summarized and discussed. In addition, reports on pharmacological interventions to reduce ROS and attenuate CIN are summarized, highlighting potential for use in clinical practice. Understanding this contributory mechanism could pave ways to improve therapeutic strategies in combating CIN.

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Section: Antioxidants As Interventions To Reduce Cinmentioning

confidence: 99%

Section: Interventions Targeting Ros For Cin Prevention: Evidence Fromentioning

confidence: 99%

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Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Kusirisin

Chattipakorn

2020

J Transl Med

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“…Similarly, some with antioxidant properties had been shown to probably reduce oxidative stress by increasing the levels of SOD and glutathione to play a renoprotective role in the progression of CIN. [23][24] (4) Several studies have indicated that atorvastatin may play a role in preventing contrastinduced renal cell apoptosis by inhibiting the c-Jun N-terminal kinase/p38 19 and Rho/Rho-associated protein kinase 25 pathway.…”

Section: Discussionmentioning

confidence: 99%

High Loading Dose of Atorvastatin for the Prevention of Serum Creatinine and Cystatin C-Based Contrast-Induced Nephropathy Following Percutaneous Coronary Intervention

Liang

Yang

2018

Angiology

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The aim of this study is to assess the efficacy of high-dose atorvastatin on the prevention of contrast-induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention and observe the incidence of cystatin C (CyC)-based CIN. A total of 496 patients with ACS were randomly assigned to either the control group (247 patients receiving conventional dose atorvastatin 10 mg daily from 1 day before to 3 days after contrast administration) or the high-dose atorvastatin group (249 patients receiving atorvastatin 40 mg daily for the same perioperative period). The baseline characteristics of the 2 groups were similar. The primary end point of serum creatinine (SCr)-based CIN occurred in 31 patients in the control group and 16 patients in the high-dose atorvastatin group (12.6% vs 6.4%; P = .02). Cystatin C-based CIN developed in 90 patients in the control group and 46 patients in the high-dose atorvastatin group (36.4% vs 18.5%; P < .001). A multivariable analysis revealed that high-dose atorvastatin was independently associated with a decreased risk of CIN. Our study demonstrated that prophylactic treatment with high-dose atorvastatin reduced the risk of both SCr and CyC-based CIN and suggested that CyC was a more reliable marker for early diagnosis of CIN compared with SCr.

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“…However, there is clear evidence that the rapidly dividing cells of the reproductive system will be damaged during HSG ( 8 , 9 ). There has been a great deal of research into minimizing the cellular damage to reproductive cells caused by HSG, as well as studies into reducing the negative effects of ionizing radiation and iodinated contrast media on other organ systems ( 10 , 11 , 12 , 13 ). However, there is no totally effective method of protection currently available so that minimum doses of ionizing radiation and the use of contrast, only when absolutely necessary, are the mainstays of reducing the deleterious effects of imaging studies.…”

Section: Introductionmentioning

confidence: 99%

The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study

Pek¹,

Göret²,

Hacıvelioğlu³

et al. 2020

J Turkish German Gynecol Assoc

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Objective: Previous studies have shown that damage occurs to internal genital tract during hysterosalpingography (HSG). The aim was to show that endometrial and tubal epithelium underwent free radical damage during HSG in an animal model. Material and Methods: Forty rats were evaluated in five different groups. Two groups received ionizing radiation (15-20 miliRad three times) only. Two further groups received ionizing radiation in combination with iohexol (1-2 mL). The remaining group served as control. Groups were evaluated after seven and forty-two days. Inflammation and cellular changes were evaluated histopathologically. Cellular activity of antioxidant enzymes was assessed immunohistochemically. Results: Inflammation, and cellular changes were detected at certain rates in all groups (p<0.001). Glutathione reductase, catalase, superoxide dismutase, glutathione S-transferase activities were found to be increased after the HSG (p<0.001). Conclusion: It is obvious that the cell suffers acute and chronic damage during HSG due to both radioactivity and chemicals. Although there is a lot of research done before, there is no definitive method yet to protect against the harmful effects of iodinated contrast agents and ionizing radiation. So, new methods need to be explored to protect cells and tissues from reactive oxygen radical damage caused by HSG.

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A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine

Cited by 15 publications

References 55 publications

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

High Loading Dose of Atorvastatin for the Prevention of Serum Creatinine and Cystatin C-Based Contrast-Induced Nephropathy Following Percutaneous Coronary Intervention

The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study

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