A Novel Approach to Calculating Small Intestine Length Based on Magnetic Resonance Enterography

Wilson, Nicole A.; Park, Hyung Soon; Lee, Kyoung Soub; Barron, Lauren; Warner, Brad W.

doi:10.1016/j.jamcollsurg.2017.04.009

Cited by 8 publications

(9 citation statements)

References 11 publications

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“…Mice were euthanised at 10 dpi by CO 2 exposure and liver tissue, serum, and faeces collected. The luminal contents of the duodenum, jejunum, ileum, caecum, and colon were sampled by flushing 1.0 mL of sterile phosphate buffer saline through each section of the gut and collecting the contents (Figure 8) (Note: individual sectional length determined by the previous studies [57,58]). Serum (collected by cardiac bleed) and liver tissue samples were used as representatives for indirect and cross-organ effects of C. parvum infection.…”

Section: Mouse Infection Modelmentioning

confidence: 99%

Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model

et al. 2021

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Cryptosporidiosis is a major human health concern globally. Despite well-established methods, misdiagnosis remains common. Our understanding of the cryptosporidiosis biochemical mechanism remains limited, compounding the difficulty of clinical diagnosis. Here, we used a systems biology approach to investigate the underlying biochemical interactions in C57BL/6J mice infected with Cryptosporidium parvum. Faecal samples were collected daily following infection. Blood, liver tissues and luminal contents were collected 10 days post infection. High-resolution liquid chromatography and low-resolution gas chromatography coupled with mass spectrometry were used to analyse the proteomes and metabolomes of these samples. Faeces and luminal contents were additionally subjected to 16S rRNA gene sequencing. Univariate and multivariate statistical analysis of the acquired data illustrated altered host and microbial energy pathways during infection. Glycolysis/citrate cycle metabolites were depleted, while short-chain fatty acids and D-amino acids accumulated. An increased abundance of bacteria associated with a stressed gut environment was seen. Host proteins involved in energy pathways and Lactobacillus glyceraldehyde-3-phosphate dehydrogenase were upregulated during cryptosporidiosis. Liver oxalate also increased during infection. Microbiome–parasite relationships were observed to be more influential than the host–parasite association in mediating major biochemical changes in the mouse gut during cryptosporidiosis. Defining this parasite–microbiome interaction is the first step towards building a comprehensive cryptosporidiosis model towards biomarker discovery, and rapid and accurate diagnostics.

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Section: Mouse Infection Modelmentioning

confidence: 99%

Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model

et al. 2021

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“…Wilson et al . 71 found a custom-designed algorithm to be feasible and accurate for calculation of small intestine length on true FISP images. Application of automatic software and machine learning to measure SB length may further improve these techniques, which could benefit patients with or at risk for SBS in nutritional management and surgical approach.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Technical Parameters for MR of the Small Bowel in non-IBD Conditions over the Last Ten Years

Zhou

Morelli

et al. 2019

Sci Rep

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Technical guidelines for magnetic resonance imaging (MRI) of the small bowel (SB) in the setting of inflammatory bowel diseases (IBDs) were detailed in a 2017 consensus issued by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR); however, MRI for non-IBD conditions was not addressed. Hence, we performed a systematic review collecting researches on SB MRI for non-IBDs. The literatures were then divided into morphologic group and functional group. Information about the MRI techniques, gastrointestinal preparation, and details of cine-MRI protocols was extracted. We found that a 1.5 T MRI system, prone positioning, and MR enterography were frequently utilized in clinical practice. Gadolinium contrast sequences were routinely implemented, while diffusion-weighted imaging (DWI) was much less performed. The gastrointestinal preparation varied throughout the studies. No uniform protocols for cine imaging could be established. SB MRI examinations for non-IBDs are far from standardized, especially for functional studies. Recommendations for standard parameters in cine-MRI sequences are difficult to make due to lack of evidentiary support. MRI investigations in non-IBD conditions are needed and the standardization of non-IBD imaging in clinical practice is required.

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“…Some scholars designed a special software algorithm to calculate the length of small intestine based on magnetic resonance enterography images in mice. Compared with the measured results of anatomical specimens, the mean absolute difference between the two methods was 1.8 ± 3.8 cm ( P = 0.24), and the mean percentage difference was 9.4% ± 6.0%[ 14 ].…”

Section: Ai In Small Intestine Anatomymentioning

confidence: 99%

Artificial intelligence in small intestinal diseases: Application and prospects

Yu¹,

Li²,

Yao³

et al. 2021

WJG

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The small intestine is located in the middle of the gastrointestinal tract, so small intestinal diseases are more difficult to diagnose than other gastrointestinal diseases. However, with the extensive application of artificial intelligence in the field of small intestinal diseases, with its efficient learning capacities and computational power, artificial intelligence plays an important role in the auxiliary diagnosis and prognosis prediction based on the capsule endoscopy and other examination methods, which improves the accuracy of diagnosis and prediction and reduces the workload of doctors. In this review, a comprehensive retrieval was performed on articles published up to October 2020 from PubMed and other databases. Thereby the application status of artificial intelligence in small intestinal diseases was systematically introduced, and the challenges and prospects in this field were also analyzed.

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A Novel Approach to Calculating Small Intestine Length Based on Magnetic Resonance Enterography

Cited by 8 publications

References 11 publications

Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model

Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model

A Systematic Review of Technical Parameters for MR of the Small Bowel in non-IBD Conditions over the Last Ten Years

Artificial intelligence in small intestinal diseases: Application and prospects

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