A novel approach to a controlled opening of liposomes

Yaroslavov, Alexander A.; Ефимова, А. А.; Smirnova, N. L.; Erzunov, Dmitry A.; Lukashev, N. V.; Grozdova, Irina D.; Melik‐Nubarov, N. S.

doi:10.1016/j.colsurfb.2020.110906

Cited by 13 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such LPs showed higher intracellular drug delivery and toxicity against HeLa cancer cells. Yaroslavov et al [126] induced the assembly of conventional zwitterionic EPC with an amphoteric lithocholic acid derivative 56 (Fig. 12), containing anionic and cationic groups at each end of its steroid core.…”

Section: Zwitterionic Ph-sensitive Liposomesmentioning

confidence: 99%

Stimulus-responsive liposomes for biomedical applications

Antoniou

Giofrè

Seneci

et al. 2021

Drug Discovery Today

View full text Add to dashboard Cite

Liposomes are amphipathic lipidic supramolecular aggregates able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems since long due to their favorable features, such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the possibility to introduce chemical modifications on liposomes has paved the way to smart liposome-based drug delivery systems characterized by even more tunable and disease-directed features. In this review, the different types of chemical modifications introduced so far have been highlighted, with a particular focus on internal stimuli-responsive liposomes and pro-drug activation.

show abstract

Section: Zwitterionic Ph-sensitive Liposomesmentioning

confidence: 99%

Stimulus-responsive liposomes for biomedical applications

Antoniou

Giofrè

Seneci

et al. 2021

Drug Discovery Today

View full text Add to dashboard Cite

show abstract

“…vaccine delivery, tumor diagnosis through bioimaging, MRI contrast agents, immunotherapy, chemotherapy, gene delivery, antigen delivery, antiulcer therapy, anti-inflammatory therapy, anti-infection therapy antiasthma therapy, cardiovascular therapy, colon drug delivery, etc. [60,111,112]. Tuning of this pH sensitive liposomes are highly important to use them for specific applications and various parameters e.g.…”

Section: Types Of Liposomesmentioning

confidence: 99%

Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade

Adhikari

2023

ajc

View full text Add to dashboard Cite

Liposomes have been thoroughly investigated and are utilized for various illnesses for the past few decades starting from its first discovery in 1961. Since then, therapeutic efficiency of liposomes is enhanced by increasing drug absorbance while fast deterioration and adverse effects are avoided or minimized. This will extend the biological halfway life. Liposomes are more attractive for usage as drug delivery carriers with all of these characteristics and versatility to modify their surface to create additional specific functionalities. In various phases of research, there are numerous new liposomal compositions that improve the therapeutic efficiency of new and old medicines used in pre-clinical and clinical studies. Current multimodal imaging advances aimed at better diagnosing and monitoring liposome therapies as diagnostic tools. Liposomes are major possibilities for medication delivery improvement. Recent researches show that the liposomes can be taken widely in cancer treatments. The primary properties of these structures include minimal toxicity, cytocompatibility, reduced clearance rates, tissue targeting and sustained drug release. Liposomes offer a variety of benefits as shown by approval of Doxil, as compared to traditional chemotherapy with free medication treatment. There are a multitude of liposomes depending on their size, lamellar number, shape and composition. Diagnostic, therapeutic, improved vaccination are covered by clinical use of these systems. Drug and gene delivery are two therapeutic aspects, where due to their unique characteristics liposomes might be beneficial. Several illnesses have been examined with respect to the participation of liposomes, with some good results. Cancer is a life-threatening disease. These structures have been examined in this respect, both in imaging and in chemotherapy. These investigations have resulted in different liposome compositions in different clinical stages. We take this great opportunity to present various surface functionalization strategies and bio-applications of liposomes developed during the last two decades covering the notable work published from 2011 to 2021 in this review. In addition, we provide opinions on the liposome industry, its commercial market and the prospective developments in the field of liposome technology. It is anticipated that this review will serve as a valuable resource, fostering interest and engagement among scientists worldwide in the field of liposome research.

show abstract

“…The surface charge switching enhanced the activity and targeted delivery of loaded drugs. Yaroslavov and co-workers developed pH-sensitive switches derived from lithocholic acid . This activator contains both carboxylate and triazole moieties and changes its orientation in the lipid bilayer as a function of pH to expose an ionic group to the outer environment.…”

Section: Demolition: Triggered Release Of Encapsulated Cargo From Lip...mentioning

confidence: 99%

Demolish and Rebuild: Controlling Lipid Self-Assembly toward Triggered Release and Artificial Cells

et al. 2021

View full text Add to dashboard Cite

The ability to modulate the structures of lipid membranes, predicated on our nuanced understanding of the properties that drive and alter lipid self-assembly, has opened up many exciting biological applications. In this Perspective, we focus on two endeavors in which the same principles are invoked to achieve completely opposite results. On one hand, controlled liposome decomposition enables triggered release of encapsulated cargo through the development of synthetic lipid switches that perturb lipid packing in the presence of disease-associated stimuli. In particular, recent approaches have utilized artificial lipid switches designed to undergo major conformational changes in response to a range of target conditions. On the other end of the spectrum, the ability to drive the in situ formation of lipid bilayer membranes from soluble precursors is an important component in the establishment of artificial cells. This work has culminated in chemoenzymatic strategies that enable lipid manufacturing from simple components. Herein, we describe recent advancements in these two unique undertakings that are linked by their reliance on common principles of lipid self-assembly.

show abstract

A novel approach to a controlled opening of liposomes

Cited by 13 publications

References 39 publications

Stimulus-responsive liposomes for biomedical applications

Stimulus-responsive liposomes for biomedical applications

Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade

Demolish and Rebuild: Controlling Lipid Self-Assembly toward Triggered Release and Artificial Cells

Contact Info

Product

Resources

About