A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application

Osman, Shaaban K.; Yassin, Taher M.; Mohammed, Ahmed M.; Alfayomy, Abdallah M.; Abdellatif, Ahmed A.H.; Mahdi, Wael A.; Alshehri, Sultan; Hamd, Mohamed A. El; Sarhan, Hatem A.; Ibrahim, Mohammed

doi:10.1208/s12249-022-02487-3

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…In contrast to numerous other nonsteroidal anti-inflammatory drugs (NSAIDs), tenoxicam presents specific benefits as it can be conveniently taken once a day, and there is no need for dose adjustments in older individuals or those with kidney or liver issues [2]. Although there are advantages to tenoxicam, it poses a challenge for formulation due to its low solubility in water, measuring just 0.072 mg/ml [3].…”

Section: Introductionmentioning

confidence: 99%

Tenoxicam-Tromethamine Multicomponent Crystal: Physicochemical Characteristics, Solubility, and Dissolution Evaluation

HASANAH,

AZFITRI,

FITRIANI

et al. 2024

Int J App Pharm

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Objective: Tenoxicam is classified as a nonsteroidal anti-inflammatory drug employed for managing musculoskeletal conditions. However, its effectiveness is obstructed by its restricted ability to dissolve in water. This investigation aims to create a multicomponent crystal involving tenoxicam and tromethamine to augment tenoxicam's solubility and dissolution rate. Methods: Using the solvent drop grinding technique, the multicomponent crystal was synthesized by combining tenoxicam and tromethamine in equimolar proportions. The physicochemical properties of multicomponent crystal were assessed through powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and FT-IR spectroscopy. Solubility test and dissolution rate profile were conducted to evaluate the effectiveness of multicomponent crystal formation in compared to intact tenoxicam. The solubility test occurred in CO2-free distilled water over 48 h and was quantified using UV spectrophotometry at 368 nm. Dissolution rate profiles were conducted using a USP type II dissolution apparatus in HCl 0.1 N, and CO2-free distilled water as the dissolution media. Results: The multicomponent crystal displayed distinctive characteristics in the diffractogram, including altered melting points, and shifts in the FT-IR spectrum peaks. Within the multicomponent crystal system, the solubility of tenoxicam exhibited a notable increase, specifically by a factor of 11.130. Moreover, the dissolution efficiency of tenoxicam in HCl 0.1 N solution and CO2-free distilled water showed substantial enhancements, with respective increases of 2.600-fold and 8.605-fold observed at the 60-minute mark. Conclusion: In conclusion, the tenoxicam and tromethamine multicomponent crystal formation using a solvent drop grinding technique resulted in a novel crystalline structure, enhancing the solubility and dissolution of tenoxicam both in CO2-free distilled water and HCl 0.1 N.

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Section: Introductionmentioning

confidence: 99%