A novel approach for obtaining α,β-diaminophosphonates bearing structurally diverse side chains and their interactions with transition metal ions studied by ITC

Abstract

A convenient and general reaction is presented for the preparation of diaminophosphonates further evaluated as chelators of metal ions.

N-Functionalization of β-aminophosphonates: cytotoxic effects of the new derivatives

“…α,β-Diaminophosphonates were also described as promising new targets. 34 In the last decade, the senior author of this article together with co-workers elaborated the "green", microwave-assisted, solvent-free synthesis of α-amino-methylphosphonates 35 including bis( phosphonoylmethyl)amines. 36,37 Recently, our group has described tandem Kabachnik-Fields reactions with the intermediacy of α-amino-methylphosphonate derivatives, and the latter species were also modified by N-acylation.…”