A novel antimicrobial strategy for bacterial infections: Gallium-based materials

Shi, Fanghui; Ma, Sisi; Liu, Sen; Xu, Rui; Chen, Bin; Ye, Wei; Sun, Jing

doi:10.1016/j.colcom.2023.100735

Cited by 9 publications

(4 citation statements)

References 94 publications

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“…The main disadvantage of these approaches is that their antimicrobial activity decreases over time [ 23 ]. Due to this, the most advantageous approach is the chemical modification of polymers, i.e., the covalent incorporation of antimicrobial fragments [ 24 ]. The main application areas for antimicrobial polymers are the medicine, textile and food industries [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Saunoryte,

Navaruckiene,

Grauzeliene

et al. 2024

Polymers

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In this paper, for the first time, photopolymers were synthesized from glycerol acrylates with different numbers of functional groups, 2-hydroxy-3-phenoxypropyl acrylate, glycerol dimethacrylate or glycerol trimethacrylate, without and with the addition of vanillin styrene. The photocuring kinetics were monitored by real-time photorheometry. The mechanical, rheological, thermal, antimicrobial and shape-memory properties of the photopolymers were investigated. All polymers synthesized demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as antifungal activity against Aspergillus flavus and Aspergillus niger. 2-Hydroxy-3-phenoxypropyl acrylate-based polymers showed thermoresponsive shape-memory behavior. They were able to maintain their temporary shape below the glass transition temperature and return to their permanent shape above the glass transition temperature. Synthesized photopolymers have potential to be used as sustainable polymers in a wide range of applications such as biomedicine, photonics, electronics, robotics, etc.

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Section: Introductionmentioning

confidence: 99%

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Saunoryte,

Navaruckiene,

Grauzeliene

et al. 2024

Polymers

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“…Contamination of medical device surfaces with bacterial adhesion and biofilm formation can lead to treatment failure or even death. − Free bacteria gradually attach to the surfaces of medical devices. Once stable adhesion occurs, bacteria form extracellular polymeric substances to recruit other planktonic bacteria and eventually form a bacterial biofilm. − Hence, the prevention of bacterial biofilm formation and the removal of existing biofilms are two major antimicrobial strategies for medical device surfaces. The strategy of preventing bacterial biofilm formation aims to intercept the formation process of biofilms at the source, playing a crucial role in preventing microbial contamination.…”

Section: Introductionmentioning

confidence: 99%

“…The research found that the application of Ga 3+ can alleviate these two problems. Ga 3+ shares similar properties with Fe 3+ , such as ionic radius, ionization potential, ionization affinity, and atomic radius . These shared properties pose challenges for bacterial uptake systems in differentiating between Ga 3+ and Fe 3+ , allowing Ga 3+ to interfere with and displace bacterial uptake of Fe 3+ . , Iron is an essential element required for the normal biological activities of almost all pathogenic bacteria .…”

Section: Introductionmentioning

confidence: 99%

Dopamine-Chelated Metal–Organic Framework Nanostructure-Based Coatings as a Photodynamic Therapy Amplifier

Shi,

Ma,

Liu

et al. 2024

ACS Appl. Nano Mater.

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In recent years, photodynamic therapy (PDT) has been frequently applied in the treatment of bacterial infections. However, reactive oxygen species (ROS) produced by PDT have a short lifetime and operating distance, resulting in a generally inadequate therapeutic efficacy. Herein, we report the fabrication of a nanostructure-based PDT amplifier composite coating via selfassembly between MIL-96 (Ga) particles, dopamine (DA), and methylene blue (MB). The coatings exhibited a bacterial inhibition rate of over 99% after 5 min of red light exposure. Based on the chelation between Ga 3+ and DA, these metal−organic frameworks (MOFs) can stably adhere to surfaces of various substrates, such as polyurethane (PU), nonwoven, and titanium (Ti) alloy. The Ga-MOF can slowly and consistently release Ga 3+ , avoiding the rapid hydration of Ga 3+ . Furthermore, after loading MB, the nanostructure-based Ga-MOF composite coating exhibits PDT capability triggered by red light (660 nm). By blocking of bacterial iron metabolism through Ga 3+ , the coating disrupts bacterial antioxidant systems and significantly enhances PDT efficacy. In addition, the iron block antibacterial therapy (IBAT)/PDT coating also shows excellent in vitro biocompatibility. This work provides an innovative antibacterial strategy for medical device surfaces.

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“…LMs have gained significant interest in many fields due to their low melting point, possessing both liquid and metallic properties. There is increasing interest in bioapplications of Ga-based LMs, due to their interesting properties and possible interactions. − Recently, a few studies have emerged indicating Ga LMs might possess innate antibacterial properties, − as well as several recent reviews. − Multiple studies have also demonstrated antibacterial applications of Ga LMs in combination with other metals − as well as nonmetals. − There are several studies that demonstrate antibacterial activity of Ga nanoparticles that are not in the liquid state. ,− Finally, a few studies also utilize metallic Ga to functionalize phosphate-based glass for antibacterial activity. − These studies indicate that the antibacterial mechanism is the release of Ga 3+ ions. According to one study, solid gallium oxide particles (Ga 2 O 3 ) do not exhibit any substantial antibacterial activity against planktonic bacterial cells .…”

Section: Introductionmentioning

confidence: 99%

Metallic Gallium Droplets Exhibit Poor Antibacterial Properties

Leong,

Parker,

Shaw

et al. 2023

ACS Appl. Mater. Interfaces

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The rise of antibiotic resistance in pathogenic bacteria requires new therapeutics to be developed. Several metallic nanoparticles such as those made from silver, copper, and zinc have shown significant antibacterial activity, in part due to metal ion leaching. Ga 3+ containing compounds have also been shown to have antibacterial properties. Accordingly, it is estimated that metallic Ga droplets may be antibacterial, and some studies to date have confirmed this. Here, multiple concentrations of Ga droplets were tested against the antibiotic resistant Gram-positive bacteria methicillin-resistantStaphylococcus aureus (MRSA) and the Gram-negative bacteria Pseudomonas aeruginosa (P. aeruginosa) Despite a high concentration (2 mg/mL), Ga droplets had only modest antibacterial activity against both bacteria after 24 h of interaction. Finally, we demonstrated that Ga droplets were easily functionalized through a galvanic replacement reaction to develop antibacterial particles with copper and silver demonstrating a total detectable reduction of MRSA and >96% reduction ofP. aeruginosa. Altogether, these results contradict previous literature and show that Ga droplets demonstrate no antibacterial activity at concentrations comparable to those of conventional antibiotics and well-established antibacterial nanomaterials and only modest antibacterial activity at very high concentrations. However, we demonstrate that their antibacterial activity can be easily enhanced by functionalization.

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A novel antimicrobial strategy for bacterial infections: Gallium-based materials

Cited by 9 publications

References 94 publications

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Glycerol Acrylate-Based Photopolymers with Antimicrobial and Shape-Memory Properties

Dopamine-Chelated Metal–Organic Framework Nanostructure-Based Coatings as a Photodynamic Therapy Amplifier

Metallic Gallium Droplets Exhibit Poor Antibacterial Properties

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