A Novel Anticancer Effect of<i>Ephedra alata</i>Decne in Breast Cancer Cells

Sioud, Fairouz; Dhouafi, Zaineb; Lahmar, Aida; Elgueder, Dorra; Chekir‐Ghedira, Leila

doi:10.1080/01635581.2022.2072907

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…Trigonella foenum-graecum seeds inhibited angiogenesis in HepG2 cells, inducing cell cycle arrest at the G2/M phase after 12 and 48 hours of treatment, and a remarkable arrest at the G1/S phase after 24 hours [ 83 ]. Ephedra alata is another species with anticancer potential, significantly inhibiting cell growth and migration in 4T1 breast cancer cells in a dose and time-dependent manner [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

“…This effect was mediated by the induction of apoptosis and caspase activation, as well as the up-regulation of reactive oxygen species (ROS) production [ 78 ]. Other Asteraceae plant species, such as Artemisia herba-alba , Chamaemelum nobile , Saussurea costus , and Dittrichia viscosa , demonstrated significant anticancer properties against various cell lines, with IC 50 values ranging from 20.07 to 168.40 g/mL [ 62 , 70 – 72 ].…”

Section: Resultsmentioning

confidence: 99%

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Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Benkhaira

Ferioun

Kandsi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cancer is one of the major medical challenges, with an unacceptably high death toll worldwide. In Morocco, medicinal plants continue to play a pivotal therapeutic role despite the development of modern sanitation systems. In the current study, an ethnobotanical survey was carried out at the Moroccan national institute of oncology, Rabat, and we aimed at (1) establishing an exhaustive inventory of indigenous knowledge of Moroccan medicinal plants used to manage cancer and (2) confirming the reported ethnopharmacological uses through bibliometric review. An ethnobotanical survey was conducted with 291 cancer patients at the Moroccan National Institute of Oncology, Rabat, during a period of 4 months, from February to May 2019, through semistructured interviews. Ethnobotanical indices, including informant consensus factor (FIC), use report (UR), relative frequency citation (RFC), botanical family use value (FUV), fidelity level (FL), and index of agreement on remedies (IAR), were employed in data analyses. The survey revealed that 39 medicinal plants belonging to 27 botanical families and 38 genera were used to treat cancer. The most used ethnospecies were Aristolochia longa with the highest RFC value (0.096), followed by Nigella sativa, Ephedra alata, Euphorbia resinifera, and Lavandula dentata, éwith RFC values of 0.072, 0.054, 0.044, and 0.044, respectively. In regard to the plant families, Lamiaceae contributed the highest number of plants with five species (FUV = 0.034), followed by Asteraceae (4 species; FUV = 0.020), and Fabaceae (4 species; FUV = 0.020). The leaves are the most popular plant part used by the studied population against cancer; otherwise, decoction was the most commonly used method for remedy preparation and the highest FIC was noticed for uterine cancer treatment (0.86). Considering these findings, further investigations into the recorded plant species should be performed to assess phytochemical constituents and pharmaceutical benefits in order to identify their active compounds for any drug formulations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Benkhaira

Ferioun

Kandsi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Its use as anti-cancer herb has grown exponentially in the last decade due to widespread belief that it is an effective anti-cancer agent ( Ali-Shtayeh et al, 2016 ). Earlier studies on the anticancer activities of Ephedra species revealed Ephedra alata Decne possess anticancer effects against 4 T1 cells by inducing apopotosis ( Sioud et al, 2022 ). Another report on the anti-cancer and anti-oxidant effects of Ephedra alata and Ephedra fragilis showed that both these species are toxic to MCF-7 cells ( Soumaya et al, 2020 ) while a study from Libya on Ephedra alata showed anti-cancer activity against MCF-7 cells with an IC 50 value of 38.7 µg/ml ( Alshalmani et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the anti-cancer potential of Ephedra foeminea leaf extract on MDA-MB-231, MCF-7, 4 T1, and MCF-10 breast cancer cell lines: Cytotoxic, apoptotic and oxidative assays

Abdulkarim Alharbi,

Eldin Ahmed Abdelsalam,

Asad

et al. 2024

Saudi Pharmaceutical Journal

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“…Methanolic or ethanolic extracts made from the plant have revealed marked inhibitory effects on the proliferation of breast cancer cell lines in vitro. The activity has been associated with the presence of diverse flavonoids, phenolic acids, and proanthocyanidins [37,[91][92][93]. A recent study evidenced the induction of tumor cell apoptosis in a p53-dependent manner by an ethanolic extract of E. alata (with a specimen from Algeria) [94].…”

Section: Ephedra Alata Decnementioning

confidence: 99%

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

Chroho,

Bailly,

Bouissane

2024

Planta Med

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Ephedra species are among the most popular herbs used in traditional medicine for a long time. The ancient Chinese medical book “Treatise on Febrile Diseases” refers to the classic traditional Chinese medicine prescription Ge Gen decoction, which consists of seven herbs, including an Ephedra species. Ephedra species are utilized all over the world to treat symptoms of the common cold and coughs, and to combat major human diseases, such as asthma, cancers, diabetes, cardiovascular and digestive disorders, and microbial infections. This study aimed at identifying specific Ephedra species used traditionally in Morocco for therapeutic purposes. The plant parts, their preparation process, and the treated pathologies were identified and analyzed. The results revealed five ethnobotanically important species of Ephedra: Ephedra alata Decne, Ephedra altissima Desf., Ephedra distachya L., Ephedra fragilis Desf., and Ephedra nebrodensis Tineo. These species are used traditionally in Morocco for treating people with diabetes, cancer, rheumatism, cold and asthma, hypertension, influenza virus infection, and respiratory ailments. In addition, they are occasionally used as calefacient agents, to regulate weight, or for capillary care. Few studies have underlined the antibacterial and antioxidant activities of some of these Moroccan Ephedra species, but little information is available regarding the natural products at the origin of the bioactivities. Further phytochemical investigations and clinical data are encouraged to better support the use of these plants.

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A Novel Anticancer Effect ofEphedra alataDecne in Breast Cancer Cells

Cited by 5 publications

References 39 publications

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Moroccan Medicinal Plants Used to Treat Cancer: Ethnomedicinal Study and Insights into Pharmacological Evidence

Assessment of the anti-cancer potential of Ephedra foeminea leaf extract on MDA-MB-231, MCF-7, 4 T1, and MCF-10 breast cancer cell lines: Cytotoxic, apoptotic and oxidative assays

Ethnobotanical Uses and Pharmacological Activities of Moroccan Ephedra Species

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