A novel antibacterial dental glass‐ionomer cement

Abstract

This study reports the synthesis and evaluation of a novel non-leachable poly(quaternary ammonium salt) (PQAS)-containing antibacterial glass-ionomer cement. Fuji II LC cement was used for comparison. Compressive strength (CS) and Streptococcus mutans viability were used to evaluate strength and antibacterial activity, respectively. All specimens were conditioned in distilled water at 37 degrees C before testing. After the addition of 1-30% PQAS, both cements showed a reduction in CS, of 25-95% for Fuji II LC and 13-78% for the experimental cement, and a reduction in S. mutans viability, of 40-79% for Fuji II LC and 40-91% for the experimental cement. The experimental cement showed less CS reduction and higher antibacterial activity compared with Fuji II LC. The result also indicates that the cements are permanently antibacterial, with no leaching of PQAS. It appears that the experimental cement is a clinically attractive dental restorative that can be potentially used for longlasting restorations as a result of its high mechanical strength and permanent antibacterial function.

Experimental amine‐epoxide sealer: a physicochemical study in comparison with AH Plus and EasySeal

“…In contrast to the sealers tested in these studies, EvoSeal A includes a Quat which is covalently attached to the cured resins, thereby reducing the risk of adverse material effects or allergic reaction as a result of the release of antibacterial substances (Weng et al . ). The effectiveness of those covalently attached quats against Gram‐negative and Gram‐positive bacteria was shown recently (Mondrzyk et al .…”

Antimicrobial properties of conventional restorative filling materials and advances in antimicrobial properties of composite resins and glass ionomer cements—A literature review

“…Differences were noted between materials with different chain length [4,24,101], loading and grafting ratios of QAS. As these were increased, the antibacterial activity increased but the initial compressive strength decreased [4,100]. He [102] claim that antibiofilm effect is also dependent on which alkyl chain is substituted.…”

“…PQAS-containing cements examined showed significant long-lasting antibacterial activity [4,24,100], but were all accompanied by a reduction in compressive strength. Differences were noted between materials with different chain length [4,24,101], loading and grafting ratios of QAS.…”

Antibacterial activity of glass ionomer cement modified by zinc oxide nanoparticles

“…On the other hand, studies on the effects of zinc oxide nanoparticles associated with glass ionomer cement (GIC) are scarce (Spencer, Campbell, Buschang, Cai, & Honeyman, 2009), although such data would be important. GIC is a restorative material that shows good chemical adhesion to the dental structure, releases fluorine (Cassanho et al, 2005;Weng, Guo, Gregory, & Xie, 2010), enables restoration of fluorine after topical applications, alters acid production and the electrolytic metabolism of cariogenic microorganisms, and promotes a decrease in the number of S. mutans and plaque bacteria after restoration (Chau, Pandit, Cai, Lee, & Jeon, 2015). The fluorine released by GIC can alter the ecosystem of the bacterial plaque and affect a variety of enzymatic functions that are vital for the bacterial cell, including inhibition of enolase, phosphatase, and pyrophosphatase, eventually leading to cell death (Chau et al, 2015;Duque, Negrini, Hebling, & Spolidorio, 2005;Hotwani, Thosar, Baliga, Bundale, & Sharma, 2013).…”