A novel and simple oral colon-specific drug delivery system based on the pectin/modified nano-carbon sphere nanocomposite gel films

Wang, Shuya; Meng, Yu-jie; Li, Jun; Jinpeng, Liu; Liu, Zun-qi; Li, Deqiang

doi:10.1016/j.ijbiomac.2020.04.197

Cited by 33 publications

(9 citation statements)

References 39 publications

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“…The Ritger–Peppas model and the first-order model were applied to drug release to describe the drug release process in the alkaline region [ 51 ]. This resulted in multiple drug release mechanisms: (1) the membrane surface of 5-FU released in the simulated environment, (2) the membrane layer breaking of the PEM induced drug release in the 5-FU, (3) the high concentration of the 5-FU in the inner layer drove drug release, (4) the polymer–solvent interactions, as well as the polymer–solute interactions, meant that the pectin-Ca +2 -based films displayed a higher drug release rate, i.e., 63.89%, in simulated intestinal fluid [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

et al. 2021

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In this study, a simple method for the fabrication of highly diffusive, adsorptive and conductive eco-friendly polyelectrolyte membranes (PEMs) with sulfonate functionalized pectin and poly(vinyl alcohol)(PVA) was established. The graft-copolymers were synthesized by employing the use of potassium persulfate as a free radical initiator from pectin (PC), a carbohydrate polymer with 2-acrylamido-2-methyl-1-propanesulphonic acid (AMPS) and sodium 4-vinylbenzene sulphonate (SVBS). The PEMs were fabricated from the blends of pectin graft-copolymers (PC-g-AMPS and PC-g-SVBS) and PVA by using a solution casting method, followed by chemical crosslinking with glutaraldehyde. The composite PEMs were fabricated by mixing phosphomolybdic acid with the aforementioned blends. The PEMs were successfully characterized by FTIR, XRD, SEM, and EDAX studies. They were assessed for the controlled release of an anti-cancer drug (5-fluorouracil) and the removal of toxic metal ions (Cu2+) from aqueous media. Furthermore, the composite PEMs were evaluated for fuel cell application. The 5-fluorouracil release capacity of the PEMs was found to be 93% and 99.1% at 300 min in a phosphate buffer solution (pH = 7.4). The highest Cu2+ removal was observed at 206.7 and 190.1 mg/g. The phosphomolybdic acid-embedded PEMs showed superior methanol permeability, i.e., 6.83 × 10−5, and 5.94 × 10−5, compared to the pristine PEMs. Furthermore, the same trend was observed for the proton conductivities, i.e., 13.77 × 10−3, and 18.6 × 10−3 S/cm at 30 °C.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

et al. 2021

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“…The gelling processes described in the preceding section allow the formation of microcapsules with tailored properties for several matrices for different foods. 57,58,59–66,67,68 An important prerequisite is that the pectins applied in microcapsules should largely remain intact and protect the encapsulated food components when subject to the harsh circumstances in the stomach and upper gastrointestinal (GI) tract. 34 Pectin is, however, ideally suitable for that.…”

Section: Impact Of Pectin Structure On Release Properties In the Gutmentioning

confidence: 99%

Structure, controlled release mechanisms and health benefits of pectins as an encapsulation material for bioactive food components

et al. 2022

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“…In addition, the combination of polysaccharides with more polymers to improve their required functional properties, such as encapsulation, stability, and release of drugs, is a common practice. Pectin is a natural excellent macromolecule polymer with biocompatible and biodegradable properties that is used for targeted drug delivery [ 141 , 142 ]. Moreover, some experiments have shown that pectin has the ability to inhibit tumor growth in cancers [ 143 , 144 ].…”

Section: Combination Of Natural Products With Nanotechnology or Other Materials For Targeting The Tmementioning

confidence: 99%

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Yang

Wang

et al. 2021

IJMS

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Lung cancer is one of the most prevalent malignancies worldwide. Despite the undeniable progress in lung cancer research made over the past decade, it is still the leading cause of cancer-related deaths and continues to challenge scientists and researchers engaged in searching for therapeutics and drugs. The tumor microenvironment (TME) is recognized as one of the major hallmarks of epithelial cancers, including the majority of lung cancers, and is associated with tumorigenesis, progression, invasion, and metastasis. Targeting of the TME has received increasing attention in recent years. Natural products have historically made substantial contributions to pharmacotherapy, especially for cancer. In this review, we emphasize the role of the TME and summarize the experimental proof demonstrating the antitumor effects and underlying mechanisms of natural products that target the TME. We also review the effects of natural products used in combination with anticancer agents. Moreover, we highlight nanotechnology and other materials used to enhance the effects of natural products. Overall, our hope is that this review of these natural products will encourage more thoughts and ideas on therapeutic development to benefit lung cancer patients.

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A novel and simple oral colon-specific drug delivery system based on the pectin/modified nano-carbon sphere nanocomposite gel films

Cited by 33 publications

References 39 publications

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

Fabrication of Polyelectrolyte Membranes of Pectin Graft-Copolymers with PVA and Their Composites with Phosphomolybdic Acid for Drug Delivery, Toxic Metal Ion Removal, and Fuel Cell Applications

Structure, controlled release mechanisms and health benefits of pectins as an encapsulation material for bioactive food components

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

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