A Novel and Efficient Process to 13β-Ethyl-gon-4-ene-3,11,17-trione

Liu, Ligong; Su, Xiaoyan; Li, Zhen-Su

doi:10.1080/00397919508015460

Search citation statements

Order By: Relevance

Paper Sections

Select...

Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1995

2011

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We postulate that, considering the ease with which 52 isomerizes to its trienol form ( 54 ) under acidic conditions, it may well be that 54 is the reactive intermediate en route to 53 . Similar systems are known to react with O 2 in a similar manner, xliii,xliv and electron paramagnetic resonance (EPR)/ spin trapping studies support a stepwise radical pathway involving triplet oxygen. xlv Small scale attempts to prevent peroxidation through freeze-pump-thaw degassing were unsuccessful.…”

Section: Resultsmentioning

confidence: 79%

Synthetic studies toward (+)-cortistatin A

2011

View full text Add to dashboard Cite

We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total synthesis.

show abstract

Section: Resultsmentioning

confidence: 79%