A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent

Neto, Davino M. Andrade; Costa, Luelc Souza da; Menezes, Fernando Lima de; Fechine, Lillian Maria Uchôa Dutra; Freire, Rafael M.; Denardin, Juliano C.; Bañobre‐López, Manuel; Vasconcelos, Igor F.; Ribeiro, T. S.; Leal, Luzia Kalyne Almeida Moreira; Sousa, João Antônio Costa de; Gallo, Juan

doi:10.1016/j.apsusc.2020.148824

Cited by 32 publications

(5 citation statements)

References 100 publications

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“…Notably, a broad peak was detected at 402.0 eV assigned to −N + H−, which is attributed to nitrogen atoms from DTPMP participate in the coordination to zinc atoms in Zn x −DTPMP complex. 39 Thus, the hydrophobic and zincophilic groups are simultaneously present in the layer during the preparation process. Also, such results verify that cross-linked structure with strong chemical bond is formed between Zn metal and organic zinc chelates coating, rather than simple weak adsorption, enabling good adhesion, and stability.…”

Section: Resultsmentioning

confidence: 99%

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A Functional Organic Zinc-Chelate Formation with Nanoscaled Granular Structure Enabling Long-Term and Dendrite-Free Zn Anodes

et al. 2022

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Aqueous Zn metal batteries suffer from rapid cycling deterioration due to the severe water corrosion and dendrite growth o n Z n a n o d e s . H e r e i n , a h i g h l y a n t i w a t e r Z n xdiethylenetriaminepenta(methylene-phosphonic acid) interface layer with good zinc affinity and special nanoscaled 3D granular structure is designed on Zn metal to address these problems. Experimental results combined with theoretical analysis and COMSOL simulations reveal that the hydrophobic groups in such Zn-based organic complex are the decisive factor in preventing H 2 O from damaging Zn anode surface. The massive Zn 2+ attractive sites formed by interaction of methylene-phosphonic acid groups and Zn cause ion channel for fast zinc-ion adsorption and migration. And the developed nano granular architecture on the surface induces redistributed Zn 2+ ion flux to realize homogenization with smooth and compact surface deposition. Under the synergism, such modified anodes exhibit long cycling lifespan over 1300 h with a relatively low polarization voltage at 5 mA cm −2 . Also, the assembled full cells (including Zn//V 2 O 5 and Zn//MnO 2 cell) based on this anode are also demonstrated. The work provides a simple, low cost, and efficient pathway by combining the two concepts of structural design and constructing protective layers on the surface to prepare high-performance Zn anodes toward prospering aqueous zinc−metal batteries.

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Section: Resultsmentioning

confidence: 99%

“…(Figure f). Notably, a broad peak was detected at 402.0 eV assigned to −N + H–, which is attributed to nitrogen atoms from DTPMP participate in the coordination to zinc atoms in Zn x –DTPMP complex . Thus, the hydrophobic and zincophilic groups are simultaneously present in the layer during the preparation process.…”

Section: Resultsmentioning

confidence: 99%

A Functional Organic Zinc-Chelate Formation with Nanoscaled Granular Structure Enabling Long-Term and Dendrite-Free Zn Anodes

et al. 2022

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“…Coatings of bisphosphonate successfully inhibited the corrosion of biodegradable Zn-based biomaterials [29] and reduced the cytotoxicity of the NaYF 4 -based upconverting nanoparticles, magnetite, etc. [30][31][32]. One such bisphosphonate is alendronic acid (AL) (i.e., (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid), an amine-terminated bisphosphonic acid that is supposed to bond strongly with its two phosphonic groups to the surface of metal oxides.…”

Section: Introductionmentioning

confidence: 99%

New Insights into Amino-Functionalization of Magnetic Nanoplatelets with Silanes and Phosphonates

et al. 2022

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Magnetic nanoplatelets (NPLs) based on barium hexaferrite (BaFe12O19) are suitable for many applications because of their uniaxial magneto-crystalline anisotropy. Novel materials, such as ferroic liquids, magneto-optic composites, and contrast agents for medical diagnostics, were developed by specific surface functionalization of the barium hexaferrite NPLs. Our aim was to amino-functionalize the NPLs’ surfaces towards new materials and applications. The amino-functionalization of oxide surfaces is challenging and has not yet been reported for barium hexaferrite NPLs. We selected two amine ligands with two different anchoring groups: an amino-silane and an amino-phosphonate. We studied the effect of the anchoring group, backbone structure, and processing conditions on the formation of the respective surface coatings. The core and coated NPLs were examined with transmission electron microscopy, and their room-temperature magnetic properties were measured. The formation of coatings was followed by electrokinetic measurements, infrared and mass spectroscopies, and thermogravimetric analysis. The most efficient amino-functionalization was enabled by (i) amino-silanization of the NPLs precoated with amorphous silica with (3-aminopropyl)triethoxysilane and (ii) slow addition of amino-phosphonate (i.e., sodium alendronate) to the acidified NPL suspension at 80 °C.

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“…In-vivo and in vitro investigations indicated that the resulting multifunctional NPs showed high selectivity in recognition of HER-2 receptors conveyed on MCF tumor cells. Recent research by Neto et al [128] has focused on methylene phosphonic acid -diemethylenetriaminepenta (DTPMP) as a capping agent for Fe3O4 and compared two synthesis methods: hydrothermal and sonochemical. The sonochemical method was faster resulting in MNPs with a better performance as a T2 MRI agent.…”

Section: Magnetic Diagnosticsmentioning

confidence: 99%

Magnetic Spinel Ferrite Nanoparticles: From Synthesis to Biomedical Applications

Nikolic¹

2023

Magnetic Nanoparticles for Biomedical Applications

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Spinel ferrites are a widely investigated and applied class of materials with a cubic spinel lattice structure. Their unique multifunctional properties (magnetic characteristics, tunable shape/size, large number of active surface sites, high values of specific surface area, good chemical stability, and possibilities for enhancing properties through surface modification) influenced by the synthesis procedure make them attractive for biomedical applications as magnetic nanoparticles in drug delivery to a set target, magnetic hyperthermia, tissue engineering, magnetic extraction of biological components and magnetic diagnostics. In this review, we give an overview of up-to-date synthesis procedures for obtaining magnetic spinel nanoparticles and nanocomposites with optimal properties for biomedical applications.

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A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent

Cited by 32 publications

References 100 publications

A Functional Organic Zinc-Chelate Formation with Nanoscaled Granular Structure Enabling Long-Term and Dendrite-Free Zn Anodes

A Functional Organic Zinc-Chelate Formation with Nanoscaled Granular Structure Enabling Long-Term and Dendrite-Free Zn Anodes

New Insights into Amino-Functionalization of Magnetic Nanoplatelets with Silanes and Phosphonates

Magnetic Spinel Ferrite Nanoparticles: From Synthesis to Biomedical Applications

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