A novel amide stationary phase for hydrophilic interaction liquid chromatography and ion chromatography

Shen, Guobin; Zhang, FeiFang; Yang, Bingcheng; Chu, Changhu; Liang, Xinmiao

doi:10.1016/j.talanta.2013.04.046

Cited by 42 publications

(12 citation statements)

References 18 publications

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“…The key to develop MMC lies in the improvement of stationary phases with mixed-mode or multiple interactions. So far, two or more than two modes stationary phases have been reported, such as reversed-phase liquid chromatography (RPLC)/hydrophilic interaction chromatography (HILIC) [4][5][6], RPLC/ion-exchange chromatography (IEC) [7][8][9], HIILC/IEC [10,11], RPLC/HIILC/IEC [12,13], etc. However, the literatures of HIILC/IEC mixed-mode stationary phase are relatively less.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Yang

Liu

Chen

et al. 2016

Journal of Chromatography A

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Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Yang

Liu

Chen

et al. 2016

Journal of Chromatography A

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“…The new mixed‐mode HILIC stationary phase embedded with multiple groups with different characteristics could provide better separation selectivity for complex samples within a single column, based on multiple retention mechanisms . Up to now, various mixed‐mode HILIC stationary phases have been reported and further used for separation of both small molecules and macromolecules, including HILIC/RPLC , HILIC/ion exchange chromatography (IEC) , and HIILC/RPLC/IEC . Among these, HILIC/RPLC mixed‐mode stationary phases are the most promising stationary phases due to their excellent orthogonality and complementarity.…”

Section: Introductionmentioning

confidence: 99%

Imidazolium‐embedded iodoacetamide‐functionalized silica‐based stationary phase for hydrophilic interaction/reversed‐phase mixed‐mode chromatography

Wang¹,

Zhang

et al. 2016

J of Separation Science

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A novel imidazolium-embedded iodoacetamide-functionalized silica-based stationary phase has been prepared by surface radical chain-transfer polymerization. The stationary phase was characterized by Fourier transform infrared spectrometry, thermogravimetric analysis, and element analysis. Fast and efficient separations of polar analytes, such as nucleosides and nucleic acid bases, water-soluble vitamins and saponins, were well achieved in hydrophilic interaction chromatography mode. Additionally, a mixed mode of hydrophilic interaction and reversed-phase could be also obtained in the analysis of polar and nonpolar compounds, including weak acidic phenols, basic anilines and positional isomers, with high resolution and molecular-planarity selectivity, outperforming the commercially available amino column. Moreover, simultaneous separation of polar and nonpolar compounds was also achieved. In conclusion, the multimodal retention capabilities of the imidazolium-embedded iodoacetamide-functionalized silica-based column could offer a wide range of retention behavior and flexible selectivity toward hydrophilic and hydrophobic compounds.

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“…Along with increasing popularity of HILIC, the development of novel HILIC stationary phases (SPs) has received much attention [2][3][4][5][6]. The majority of HILIC SPs are based on silica gel grafted with many kinds of functional groups, e.g., neutral (amide [8], polyvinyl alcohol [9], etc. ), charged (e.g., amino [10] and arginine [11]), and zwitterionic [12].…”

Section: Introductionmentioning

confidence: 99%

A hyperbranched polyethylenimine functionalized stationary phase for hydrophilic interaction liquid chromatography

et al. 2016

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A hyperbranched stationary phase for hydrophilic interaction liquid chromatography (HILIC) has been prepared by grafting polyethylenimine (PEI) onto silica gel (termed as PEI-Sil). Rich primary, secondary, and tertiary amino groups associated with PEI render its good hydrophility. More importantly, the hyperbranched structure of PEI molecule is greatly helpful in improving interaction with polar analytes. For several kinds of model polar compounds, including organic acids, nucleosides, nucleic acid bases, amino acids, cephalosporins, and non-reducing sugars, PEI-Sil demonstrated excellent separation performance in terms of running stability, reproducibility, and separation efficiency (e.g., plate count ~74,000/m). In addition, PEI-Sil also exhibited much better separation selectivity toward inorganic anions when operated in the mode of ion chromatography relative to a commercial amino propyl-bonded column.

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A novel amide stationary phase for hydrophilic interaction liquid chromatography and ion chromatography

Cited by 42 publications

References 18 publications

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

Imidazolium‐embedded iodoacetamide‐functionalized silica‐based stationary phase for hydrophilic interaction/reversed‐phase mixed‐mode chromatography

A hyperbranched polyethylenimine functionalized stationary phase for hydrophilic interaction liquid chromatography

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