A novel adverse effect of the BNT162b2 mRNA vaccine: First episode of acute mania with psychotic features

First episode psychosis following receipt of first dose of COVID-19 vaccine: A case report

“…There are few case reports of development of psychosis after administration of vaccines for rabies ( Bhojani et al, 2014 ), yellow fever ( Romeo et al, 2021 ), smallpox, typhus and influenza. With respect to COVID-19 vaccine, few published case report has documented the association of psychosis with the use of vaccine and some of the reports indicate that psychosis could be an outcome of autoimmune encephalitis ( Reinfeld et al, 2021 ; Roberts et al, 2021 ; Takata et al, 2021 ; Yesilkaya et al, 2021 ).…”

“…Studies have shown that SAR-CoV-2 is known to trigger a powerful immune response, which includes the release of large amounts of pro-inflammatory cytokines. It is hypothesized that psychosis may be related to rapid increase in the proinflammatory response and activated autoimmune mechanism ( Yesilkaya et al, 2021 ). The MRI findings of tiny T2/FLAIR hyperintensities in deep white matter in bilateral fronto-parietal lobes in the index case could be indicators of the endothelial and autoimmune activation, as seen in autoimmune encephalitis.…”

“…There is limited data with respect to the psychiatric side effects of the COVID-19 vaccine. Few case reports have documented new onset psychosis after the use of messenger-ribonucleic acid (mRNA) based COVID vaccine ( Reinfeld et al, 2021 ; Roberts et al, 2021 ; Takata et al, 2021 ; Yesilkaya et al, 2021 ). Considering the limited data, in this report we present a case of new onset psychosis, following the use of Covishield vaccine [local version of AstraZeneca's Vaxzevria (Adenovirus vector vaccine)].…”

Psychiatric adverse reactions to COVID-19 vaccines: A rapid review of published case reports

“… Giné-Servén et al, 2021 Not mentioned AstraZeneca COVID-19 vaccine (Viral vector vaccine) Psychosis (2 cases) Acute (7 hours and 12 days) Cycloid psychosis-like phenotype and marked cognitive impairment 8. Yesilkaya et al, 2021 42/M First dose of the BNT162b2 mRNA (mRNA vaccine) Mania with psychotic symptoms 1 day Irritability; sleeplessness; dysphoric mood; increased psychomotor activity; persecutory and referential delusions; loosening of associations 57/M Second dose of the BNT162b2 mRNA vaccine (mRNA vaccine) Mania with psychotic symptoms Same day Increased speech; increased psychomotor activity; decreased sleep; nihilistic delusion 9. Uvais, 2021 74/M First dose of ChAdOx1-S/nCoV- 19 vaccine (Viral vector vaccine) Depression 2 days Low mood, dryness of mouth, lack of interest in activities, marked reduction in appetite, and difficulty in initiating sleep.…”

“…Both of them had dysphoric mood, irritability, increased speech, delusions, and absent insight. One of them developed symptoms on the same day of 2 nd dose of BNT162b2 mRNA vaccine and the other patient developed symptoms one day after his 1 st dose ( Yesilkaya et al, 2021 ). Another 74-year-old male developed depression after receiving the 1 st dose of ChAdOx1-S/nCoV- 19 adenoviral vector vaccine.…”