“…These methods, commonly known as comparative modelling techniques, are suitable under some restrictions, to produce models able to be used as sources for protein engineering (Colombres et al, 2008;Eyzaguirre et al, 2004) and computer-based drug design Lizama et al, 2009;Vasquez et al, 2007), to explore structure-function relationships (Artigas et al, 2008b;Barria et al, 2009;Carvajal et al, 2003;Ehrenfeld et al, 2008;Stange et al, 2008;Strobel et al, 2005;Tischler et al, 2005), and signal-transducing mechanisms (Gonzalez et al, 2008;Inestrosa et al, 2005;Strobel et al, 2004), among a variety of applications.…”