A novel activatable AIEgen fluorescent probe for peroxynitrite detection and its application in EC1 cells

A selective and sensitive near-infrared fluorescent probe for real-time detection of Cu(i)

“…In the past decade, a number of uorescent probes have been designed for copper detection. [26][27][28][29][30] Among this collection, NIR uorescent probes stand out due to their unique properties of high penetration through tissues, [31][32][33][34] low auto-uorescence and less photodamage. 35,36 38,39 Although these probes offer a promising strategy for intravital noninvasive quantitative imaging, they cannot completely discriminate Cu + from other interfering cations, such as Cu 2+ , Co 2+ or Hg 2+ .…”

Malononitrile as the ‘double-edged sword’ of passivation-activation regulating two ICT to highly sensitive and accurate ratiometric fluorescent detection for hypochlorous acid in biological system

“…In addition, we also studied the limits of AI , and observed a good linear relationship I 495 in the range of 0−50 μM. The LOD of AI for HOCl (3σ/slope) [ [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] ] was calculated to be 0.84 μM ( Fig. 4 A).…”

“…On the other hand, the excessive HOCl could cause various diseases such as cardiovascular disease [ 8 ], arthritis [ 9 ], arteriosclerosis [ 10 ] and cancer [ 11 , 12 ]. Therefore, it was of profound significance to realize accurate detection of HOCl in vivo [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] ].…”

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

“…In 2020, Ye, Zhang, and Cao reported a new activatable fluorescent probe 59a based on a quinolone‐malononitrile (QM) fluorogen platform for sensing of ONOO − . [ 157 ] In vitro experimental results demonstrated that probe 59a possessed a fast response time, high sensitivity (DL, 27.5 nM), and a large Stokes shift (190 nm) for detection of ONOO − . Moreover, owing to its good biocompatibility, probe 59a was successfully used to image endogenous ONOO − in living EC1 cells.…”