A novel acrylic acid-Schizochytrium sp. bio-based polymer: Design, synthesis, and properties

Olvera‐Sosa, Miguel; Rosales‐Mendoza, Sergio; García-Briones, Gabriela S.; Betancourt-Mendiola, Lourdes; González‐Ortega, Omar; Palestino, Gabriela

doi:10.1016/j.mtcomm.2021.102029

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…Wound dressings play a crucial role in dealing with the increasing problem of wounds, promoting a healthy wound repair. A moist environment can accelerate the process of wound healing by preventing dehydration, enhancing angiogenesis and collagen synthesis. , Hydrogels are highly biocompatible and can be biodegradable or non-biodegradable solid frameworks that provide a physical interface for the adsorption and immobilization of biomolecules, including proteins, growth factors, as well as other biologically active biomaterials. − Hydrogels can simulate human soft tissues due to their unique three-dimensional (3D) porous matrix, flexibility, and high-water content and have been pursued as promising materials for specific drug delivery and wound healing applications. , Fighting infections is one of the hurdles in wound healing, and wound dressings with antibacterial activity can prove to be beneficial in overcoming wound infections. Similarly, antioxidant dressings can help in scavenging the over-produced reactive oxygen species (ROS) that might result in DNA damage and oxidative stress .…”

Section: Introductionmentioning

confidence: 99%

“…Hitherto, various natural materials have been explored as conventional medicine to treat wound damage and skin diseases, with the goal of improving the healing process and lowering the cost of raw materials . Of note, bio-based polymers by incorporating Chlorella sorokiniana biomass within the polymer matrix as a filler can instill them with tuneable properties Chlorella sp.…”

Section: Introductionmentioning

confidence: 99%

“…19 Of note, bio-based polymers by incorporating Chlorella sorokiniana biomass within the polymer matrix as a filler can instill them with tuneable properties. 9 Chlorella sp. is a renewable source of bioactive compounds that are "generally regarded as safe" (GRAS).…”

Section: Introductionmentioning

confidence: 99%

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Algal Biomass-Loaded Hydrogel Scaffolds as a Biomimetic Platform with Antibacterial and Wound Healing Activities

Agarwal

Kumar

Garg

et al. 2022

ACS Appl. Polym. Mater.

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The confluence of hydrogel scaffolds and dried algal biomass (AB), consisting of all the bioactive compounds, offers the possibility to facilitate wound healing while simultaneously instilling antibacterial benefits. For this purpose, a singlestep synthesis of algal (Chlorella sorokiniana) biomass-loaded hydrogel scaffolds (AHS) was achieved. C. sorokiniana has been used in different areas for several years and has proved attractive to the pharmaceutical and cosmetic industries. Of note, the presence of phytochemicals and various bioactive compounds provides an added health benefit. Hitherto, we report AHS with accelerated wound healing along with potent antiinflammatory and antibacterial properties. AHS consisting of different concentrations of AB was applied for 14 days on excisional wounds in mice. Microscopic analyses, assessment of proinflammatory and anti-inflammatory cytokines, and histological studies were performed to investigate wound healing. These scaffolds were extensively characterized and studied using Fourier transform infrared, X-ray diffraction, Raman, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, swelling, rheological, thermal, and mechanical analyses. AHS have excellent biocompatibility in addition to significant antibacterial activity against Escherichia coli (99%) and Staphylococcus aureus (98%). We believe that the as-synthesized AHS have the potential to broaden the arsenal of more effective wound healing processes along with antibacterial activities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Algal Biomass-Loaded Hydrogel Scaffolds as a Biomimetic Platform with Antibacterial and Wound Healing Activities

Agarwal

Kumar

Garg

et al. 2022

ACS Appl. Polym. Mater.

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“…It is believed that the increase in culture medium viscosity observed in the microorganism-mediated processes, including Schizochytrium sp., is largely due to the production of extracellular polymeric substances (EPS) [41,42]. Apart from technological difficulties and complications in establishing a commercial scale of high-density cultures, the viscosity increase caused by polysaccharide production may suppress lipid accumulation in cells and DHA production [43]. Therefore, it seems advisable to conduct a study to monitor culture viscosity and adjust aeration parameters to ensure the highest effectiveness of oxygen transfer to cells as the method of oxygen supply determines its solubility in the culture medium in aerobic biotechnological processes [44,45].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Concentration of Extracellular Polymeric Substances (EPS) and Aeration Intensity on Waste Glycerol Valorization by Docosahexaenoic Acid (DHA) Produced in Heterotrophic Culture of Schizochytrium sp

Kujawska¹,

Talbierz²,

Dębowski

et al. 2021

Applied Sciences

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The study aimed to determine the effectiveness of docosahexaenoic acid (DHA) production by Schizochytrium sp. biomass fed with waste glycerol depending on the concentration of extracellular polymeric substances (EPS) in the culture medium and medium aeration effectiveness. The microalgae from the genus Schizochytrium sp. were proved to be capable of producing EPS composed of glucose, galactose, mannose, fucose, and xylose. The highest EPS concentration, reaching 8.73 ± 0.09 g/dm3, was determined at the stationary growth phase. A high EPS concentration caused culture medium viscosity to increase, contributing to diminished oxygen availability for cells, lower culture effectiveness, and reduced waste glycerol conversion to DHA. The Schizochytrium sp. culture variant found optimal in terms of the obtained technological effects and operating costs was performed at the volumetric oxygen mass transfer coefficient of kLa = 600 1/h, which enabled obtaining dry cell weight (DCW) of 147.89 ± 4.77 g/dm3, lipid concentration of 69.44 ± 0.76 g/dm3, and DHA concentration in the biomass reaching 29.44 ± 0.36 g/dm3. The effectiveness of waste glycerol consumption in this variant reached 3.76 ± 0.31 g/dm3·h and 3.16 ± 0.22 g/gDCW.

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Production of a biopolymer for leather. A life cycle assessment perspective

Ballús¹,

Guix²,

Micó³

et al. 2022

Preprint

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The aim of this paper was to develop a biopolymer based on raw materials not originating from petroleum chemistry to reduce the environmental impact. To this end, an acrylic-based retanning product was designed where part of the fossil-based raw materials was replaced with biomass-derived polysaccharides. Life cycle assessment (LCA) of both the new biopolymer and a standard product was conducted to determine the environmental impact caused by each product. The biodegradability of both products was determined by BOD5/COD ratio measurement. Both products were characterized by IR, gel permeation chromatography (GPC), and Carbon-14 content. The new product was experimented as compared to standard fossil-based product, and the main properties of leathers and effluents were assessed. The results showed that fossil-based raw materials can be partially replaced with biomass derivatives while providing the leather with similar organoleptic characteristics. The new biopolymer showed higher biodegradability and better exhaustion (lower COD). LCA allowed concluding that the new biopolymer reduces the environmental impact of 4 of the 19 impact categories analyzed; in particular, the carbon footprint was reduced by 9% vs. the standard acrylic resin. Finally, a sensitivity analysis was performed where the polysaccharide derivative was replaced with a protein derivative. The analysis concluded that the protein-based biopolymer clearly reduced the environmental impact in 16 of the 19 categories studied. In this case, the carbon footprint was reduced by 47%. Therefore, the choice of the biopolymer is critical in this type of products, which may or may not reduce the environmental impact.

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A novel acrylic acid-Schizochytrium sp. bio-based polymer: Design, synthesis, and properties

Cited by 4 publications

References 34 publications

Algal Biomass-Loaded Hydrogel Scaffolds as a Biomimetic Platform with Antibacterial and Wound Healing Activities

Algal Biomass-Loaded Hydrogel Scaffolds as a Biomimetic Platform with Antibacterial and Wound Healing Activities

Effect of the Concentration of Extracellular Polymeric Substances (EPS) and Aeration Intensity on Waste Glycerol Valorization by Docosahexaenoic Acid (DHA) Produced in Heterotrophic Culture of Schizochytrium sp

Production of a biopolymer for leather. A life cycle assessment perspective

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