A novel achiral fluorescent nanoprobe for the chiral recognition of cysteine enantiomers

Expanding the Horizons of Machine Learning in Nanomaterials to Chiral Nanostructures

“…The HOMO electron levels of molecules can interact with plasmons in metal NPs [ 263,264 ] and excitons in semiconductor QDs, [ 26,265–267 ] and carbon dots [ 268 ] leading to coupling and splitting of energy levels and the appearance of a CD signal in the region of these transitions. If the molecule has multiple anchor groups, the binding mode to the NP surface determines the spatial configurations of the molecules, which affects both the chiral properties of the NPs and the molecules themselves, as well as their electronic interaction.…”

“…In almost all cases, when NP synthesis is carried out in the presence of chiral ligands, this results in the induction of some type of chirality. Depending on various factors, this can lead to the formation of a chiral shape (mostly for plasmonic particles), [ 210,211,215,219,234–236,238–247 ] chiral defects in the volume and on the surface of the NP, [ 208,250 ] embedding or intercalation of chiral molecules between layers of layered materials (e.g., perovskites and layered double hydroxides) [ 279 ] and in the case of chemical bonding with the NP surface, hybridization of electronic energy levels [ 26,263–268 ] and distortion of surface atoms. [ 251 ]…”

“…The recognition of enantiomers [ 191,213,219,298,299 ] by NPs can be achieved due to the enantioselective adsorption of molecules on chiral NPs, which leads to an optical response being generated, for example, a change in the CD signal, luminescence intensity (QDs and carbon dots [ 220,268 ] ), or SERS response [ 219 ] (plasmonic particles). The optical activity of a chiral particle can also change upon the adsorption of achiral substances, such as hydrogen, lead ions, or reactive oxygen species (ROS).…”

“…The optical activity of a chiral particle can also change upon the adsorption of achiral substances, such as hydrogen, lead ions, or reactive oxygen species (ROS). [ 240 ] In addition, a chiral molecule can induce a CD response even in achiral NPs [ 268 ] and films. The bulk of studies on chiral sensing are devoted to the adsorption of chiral molecules on gold NPs and metasurfaces, which leads to the appearance of a very strong CD signal in the visible and NIR spectral region and is typically much more intense and red‐shifted than that of the molecule.…”

Construction of a pillar[5]arene-based supramolecular chiral polymer linked to aminophosphine salt for chiral recognition of enantiomers of mandelic acid

“…Therefore, realizing chiral recognition of enantiomers is of great significance in the field of analytical assays. 9 Currently, many studies have shown that, the host molecule selectively binds to the enantiomer of the guest molecule through non-covalent interactions such as hydrogen bonding, 10 metal coordination, π–π packing, 11 and/or electrostatic interactions. 12 So a number of chiral systems are reported for enantioselective recognition and separation, such as chiral metal–ligand complexes, 13 chiral polymers, 14 micelles, 15 and vesicles.…”