A novel A &gt; G polymorphism in the intron 2 of TBX3 gene is significantly associated with body size in donkeys

Gang, Wang; Li, Mei; Zhou, Jun; An, Xiaoya; Bai, Fuxia; Gao, Yuan; Li, Jingling; Li, Haijing; Lei, Chuzhao; Dang, Ruihua

doi:10.1016/j.gene.2021.145602

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…Multiple markers were identified in the intron of FAM184B in this study, and the five markers (on Chr03: 112842618, Chr03: 112844307, Chr03: 112841876, Chr03: 112846240, and Chr03: 112845554) were located on a haplotype block, suggesting that they may perform their functions together. GWAS revealed that the top variant of TBX3 was located on Chr08: 42740082, which is different from the marker identified in a previous study (Wang et al, 2021). A variant on Chr19: 19806595, located 4999 bp downstream of IHH, had the largest delta value among all loci, which was calculated with the allele frequencies of the large and small donkey populations.…”

Section: Selected Loci For Donkey Body Heightmentioning

confidence: 99%

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Genetic architectures and selection signatures of body height in Chinese indigenous donkeys revealed by next‐generation sequencing

Zhao

2022

Animal Genetics

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Section: Selected Loci For Donkey Body Heightmentioning

confidence: 99%

“…The genetic basis of body size variation in Chinese donkeys has been partially revealed, including the limited number of loci associated with TBX3 , LCORL , NCAPG , and FAM184B (Shen et al, 2021; Wang et al, 2021; Zhou et al, 2020). However, previous studies have been far from sufficient to illustrate the genetic basis of the trait.…”

Section: Introductionmentioning

confidence: 99%

Genetic architectures and selection signatures of body height in Chinese indigenous donkeys revealed by next‐generation sequencing

Zhao

2022

Animal Genetics

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“…Evidence supports that cell number is the primary factor that affects body size in mammals. [ 36 ]. Cell proliferation and apoptosis are inextricably linked to the number of cells [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Body Size Determination Related Candidate Genes in Domestic Pig Using Genome-Wide Selection Signal Analysis

Pan

Long

Yuan

et al. 2022

Animals

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This study aimed to identify the genes related to the body size of pigs by conducting genome-wide selection analysis (GWSA). We performed a GWSA scan on 50 pigs belonging to four small-bodied pig populations (Diannan small-eared pig, Bama Xiang pig, Wuzhishan pig, and Jeju black pig from South Korea) and 124 large-bodied pigs. We used the genetic parameters of the pairwise fixation index (FST) and π ratio (case/control) to screen candidate genome regions and genes related to body size. The results revealed 47,339,509 high-quality SNPs obtained from 174 individuals, while 280 interacting candidate regions were obtained from the top 1% signal windows of both parameters, along with 187 genes (e.g., ADCK4, AMDHD2, ASPN, ASS1, and ATP6V0C). The results of the candidate gene (CG) annotation showed that a series of CGs (e.g., MSTN, LTBP4, PDPK1, PKMYT1, ASS1, and STAT6) was enriched into the gene ontology terms. Moreover, molecular pathways, such as the PI3K-Akt, HIF-1, and AMPK signaling pathways, were verified to be related to body development. Overall, we identified a series of key genes that may be closely related to the body size of pigs, further elucidating the heredity basis of body shape determination in pigs and providing a theoretical reference for molecular breeding.

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“…Body size is a complex trait regulated by various genes and signal pathways. IGF1 [ 5 ], IGF2 [ 6 ], ACSL1 [ 7 ], ACSL3 [ 8 ], CDKL5 [ 9 ] and TBX3 [ 10 ] have been proven to be associated with the body size traits of Dezhou donkeys. For example, the TBX3 gene was found to be significantly associated with body height, body length and chest circumference in donkeys [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…IGF1 [ 5 ], IGF2 [ 6 ], ACSL1 [ 7 ], ACSL3 [ 8 ], CDKL5 [ 9 ] and TBX3 [ 10 ] have been proven to be associated with the body size traits of Dezhou donkeys. For example, the TBX3 gene was found to be significantly associated with body height, body length and chest circumference in donkeys [ 10 ]. In addition, Liu et al [ 11 ] showed that the TBX3 gene was significantly associated with body size in horses.…”

Section: Introductionmentioning

confidence: 99%

A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey

Wang

Shi

Liu

et al. 2022

Animals

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Several studies have shown the association between the ligand-dependent nuclear receptor compression-like protein (LCORL) gene and body size in horses, pigs and donkeys. Based on previous studies, the LCORL gene was hypothesized to be associated with growth traits and hide weight in Dezhou donkeys. In this study, we aimed to reveal the variation of the LCORL gene in the Dezhou donkey and explore whether the gene is associated with hide weight and body size. In this study, genetic polymorphisms in the LCORL gene of the Dezhou donkey were studied using targeted sequencing technology, and single nucleotide polymorphisms (SNPs) of the LCORL gene were analyzed for association with hide weight and body size in Dezhou donkeys. The results showed that there was an SNP locus situated in intron 1 of the LCORL gene. Association analysis revealed that individuals with the GG genotype had significantly higher body height, body length, chest circumference and hide weight than those with the AA genotype (p < 0.05). Therefore, the g.112558859 A > G locus can be used as a potential candidate marker affecting body size and hide weight. This study provides the foundation for breeding high-quality donkeys with high hide yield.

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A novel A > G polymorphism in the intron 2 of TBX3 gene is significantly associated with body size in donkeys

Cited by 10 publications

References 27 publications

Genetic architectures and selection signatures of body height in Chinese indigenous donkeys revealed by next‐generation sequencing

Genetic architectures and selection signatures of body height in Chinese indigenous donkeys revealed by next‐generation sequencing

Identification of Body Size Determination Related Candidate Genes in Domestic Pig Using Genome-Wide Selection Signal Analysis

A Novel A > G Polymorphism in the Intron 1 of LCORL Gene Is Significantly Associated with Hide Weight and Body Size in Dezhou Donkey

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