A novel 2D organic-inorganic hybrid 3d–4f polyoxometalate built by [Gd(α-PW11O39)2]11− units and [Cu(Dap)2]2+ bridges

Liu, Y.; Shi, Dongying; Zhao, Junwei; Wang, X. Y.; Cheng, Hongli; Chen, L. J.; Ma, P. T.; Niu, Jingyang

doi:10.1134/s1070328411080082

Cited by 5 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[63][64][65][66][67] For example, paramagnetic rare earth elements such as Gd 3+ can be easily incorporated into polytungstate (a type of POM) structures to form new molecules. [68][69][70] These Gd-containing polytungstates have been shown to be efficient magnetic resonance (MR) imaging contrast agents and exhibited better performances than those of commercial MR imaging contrast agents due to their large molecular weights and rigid structures. [71][72][73][74][75][76] In addition, due to the strong X-ray attenuation ability of Gd and W atoms in gadolinium polytungstates, these nanoclusters could also be used as efficient contrast agents for enhanced signaling in computed tomography (CT) imaging.…”

Section: Introductionmentioning

confidence: 99%

Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer

et al. 2016

View full text Add to dashboard Cite

The development of a new generation of nanoscaled theranostics with simple compositions and versatile properties to realize enhanced diagnoses and treatment outcomes and to avoid side effects is highly desirable but remains a great challenge. Here we report a new ultrasmall theranostic based on bovine serum albumin-coated GdW 10 O 36 nanoclusters (GdW 10 NCs) as multifunctional theranostics for multifunctional bio-imaging, highly effective in vitro photothermal ablation of cancer cells and in vivo radiotherapy of tumors. The as-synthesized GdW 10 NCs afford significantly enhanced computed tomography/magnetic resonance imaging signals and remarkable photothermal therapy (PTT)/radiotherapy therapy (RT) therapeutic effects for tumor treatment. Moreover, toxicity studies confirmed their low toxicity and efficient renal clearance, suggesting their potential for practical applications. These results indicated that the as-prepared GdW 10 nanoclusters are promising as multifunctional nanotheranostics for multimodal imaging-guided PTT/RT of tumors. These results also encourage the further exploration of other polyoxometalate-based multifunctional nanotheranostics for cancer diagnoses and therapy.

show abstract