“…The enzyme has been purified, and also cloned and expressed in E. coli [ 9 , 10 ]. Under native conditions, both recombinant [ 10 ] and natural [ 9 ] 17β-HSDcl form dimers. 17β-HSDcl is homologous to fungal reductases: to versicolorin reductases from Aspergillus parasiticus and Emericella nidulans , which are involved in aflatoxin biosynthesis; and to the 1,3,8-trihydroxynaphthalene reductases and 1,3,6,8-tetrahydroxynaphthalene reductases (3HNR, 4HNR) from Magnaporthe grisea , Ophiostoma floccosum and other fungi, which are involved in melanin biosynthesis [ 11 ].…”