A note on two Diophantine equations $x^2 \pm 2^a p^b = y^4$

Zhu, Hua; Soydan, Gökhan; Qin, Wei

doi:10.18514/mmn.2013.484

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…Similarly, STK microvascular density in mice increased in RAS 1 MSC, and further in RAS 1 KIM-MSC, suggesting more potent pro-angiogenic effects. This might have resulted from a larger number of MSC leading to a greater aggregate fall in oxidative stress, which contributes to renal microvascular loss [31]. Indeed, 8-OHDG expression was significantly decreased in STKs treated with KIM-MSC compared to nonmanipulated MSC.…”

Section: Discussionmentioning

confidence: 99%

Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule-1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury

Zou

Jiang

Puranik

et al. 2018

Stem Cells Translational Medicine

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Mesenchymal stem cells (MSC) have been experimentally used for kidney repair, but modest retention limits their efficacy. Cell‐surface coating allows modulating MSC homing and interaction with target cells. We coated mouse adipose tissue‐derived MSC with antibodies directed against kidney injury molecule‐1 (ab‐KIM1), which is upregulated in injured kidneys, and tested the hypothesis that this would enhance their therapeutic effects in ischemic kidney injury. Untreated MSC, ab‐KIM1‐coated MSC (KIM‐MSC), or vehicle, were injected systemically into the carotid artery of 2‐kidneys, 1‐clip mice 2 weeks after surgery. MSC retention in different organs was explored 24 hours, 48 hours, or 2 weeks after injection. Renal volume, perfusion, and oxygenation were studied 2 weeks after injection using magnetic resonance imaging in vivo, and renal inflammation, apoptosis, capillary density, and fibrosis ex vivo. The ab‐KIM1 coating had little effect on MSC viability or proliferation. The stenotic kidney showed upregulated KIM1 expression, selective homing, and greater retention of KIM‐MSC compared to untreated MSC and compared to other organs. KIM‐MSC‐injected mice improved renal perfusion and capillary density, and attenuated oxidative damage, apoptosis, and fibrosis compared to mice treated with vehicle or with native MSC. In conclusion, MSC coating with ab‐KIM1 increased their retention in the ischemic kidney and enhanced their therapeutic efficacy. This novel method may be useful to selectively target injured kidneys, and supports further development of strategies to enhance cell‐based treatment of ischemic kidney injury. Stem Cells Translational Medicine 2018;7:394–403

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Section: Discussionmentioning

confidence: 99%