A Note on the Expected Biases in Conventional Iterative Health State Valuation Protocols

Ternent, Laura; Tsuchiya, Aki

doi:10.1177/0272989x12475093

Cited by 12 publications

(11 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also did not study the EuroQol-5D or other indirect measures. The TTO and standard gamble in the present study are susceptible to a number of cognitive biases, including misspecification bias and anchoring bias, as they are in other studies [47].…”

Section: Discussionmentioning

confidence: 63%

Applicability of patient utilities as measures of overall quality of life in rheumatoid arthritis clinical trials

Ward

Guthrie

2016

Rheumatology

View full text Add to dashboard Cite

Objective. The aim was to determine whether the time trade-off (TTO) and standard gamble utilities can detect treatment-related improvement in overall quality of life in patients with active RA.Methods. We measured TTO and standard gamble utilities in 192 patients before and after escalation of anti-rheumatic treatment in a prospective longitudinal study. We also examined associations between changes in utilities and patient-reported improvement during the study, and with EULAR responses.Results. Mean TTO at baseline was 0.68 (median 0.82) and mean standard gamble 0.80 (median 0.93). Both utilities improved significantly with treatment. Standardized response means, a measure of responsiveness, were 0.37 for the TTO and 0.20 for the standard gamble, and comparable to those of two mental health measures and the CRP, but lower than other RA activity measures. Changes in utilities were not significantly associated with patient-reported improvement. The standard gamble, but not the TTO, had a graded association with EULAR responses. Conclusion.Utilities by the TTO and standard gamble were able to detect improvement in overall quality of life with anti-rheumatic treatment in patients with active RA, suggesting applicability in clinical trials. The standard gamble was associated with reference measures of improvement, although not as strongly as measures of RA activity, as expected with its generic orientation.

show abstract

Section: Discussionmentioning

confidence: 63%

Applicability of patient utilities as measures of overall quality of life in rheumatoid arthritis clinical trials

Ward

Guthrie

2016

Rheumatology

View full text Add to dashboard Cite

show abstract

“…This observation points toward some kind of preference construction, where respondents are influenced by the initial question. That is, they may be subject to an anchoring bias, as reported earlier in TTO and WTP studies (Samuelsen et al, 2012;Ternent and Tsuchiya, 2013;van Exel et al, 2006).…”

Section: Discussionmentioning

confidence: 85%

New Findings from the TTO for Income Approach to Elicit Willingness to Pay for a QALY

et al. 2014

View full text Add to dashboard Cite

ABSTRACT. Willingness to pay (WTP) elicitations suffer from various methodological problems. This paper tests a recently proposed alternative approach to value WTP for health, making use of trade-offs between income and lifetime or quality of life. We apply three experimental elicitation procedures and analyze the responses under an additive and a multiplicative utility function over health and income.We report several interesting results. First, the data are highly skewed, but if we trim the 5% lowest and highest values, we obtain plausible WTP estimates. Second, the results differ considerably between procedures, indicating that WTP estimates are sensitive to the assumed utility function.Third, respondents appear to be loss averse for both health and money, which is consistent with assumptions from prospect theory. Finally, our results also indicate that respondents are more willing to trade quality of life than life years.

show abstract

“…We are not aware of any other study in the health literature explicitly designed to test for the existence of sequence effects. Although “the typical way of neutralizing question order bias in the aggregate is to randomise the order in which different health states are valued” (Ternent & Tsuchiya, , p545) if our explanation of sequence effects is correct, randomisation will not avoid those effects. Our results (Section ) support this, as we present strong evidence of sequence effects, which are not avoided through randomisation.…”

Section: Introductionmentioning

confidence: 99%

Sequence effects in time trade‐off valuation of hypothetical health states

Prades

McHugh

Donaldson³

et al. 2019

Health Economics

View full text Add to dashboard Cite

Choice‐based stated preference methods, such as time trade‐offs (TTOs), are used to establish health state utilities informing healthcare allocation. However, little is known about the presence of (position‐dependent and precedent‐dependent) sequence effects in the valuation of health states, despite techniques requiring respondents to evaluate several health states in a sequence. This paper is the first to explicitly test for the presence of sequence effects in the health domain using a new explanation based on contrast effects and preference imprecision; the implication being that randomisation cannot avoid sequence effects. Six TTO questions were designed using the EQ‐5D‐3L descriptive system. These were grouped into two blocks of three and within each block four sequences were used. In an online survey, 1,197 Spanish respondents answered one grouping of three TTO questions. Results indicate that sequence effects can affect preferences as utilities of health states are biased downwards if preceded by a better health state and biased upwards if preceded by a worse health state. This study informs our understanding of how context effects interact with preference elicitation methods, which is essential for interpreting survey results used to inform policy.

show abstract

A Note on the Expected Biases in Conventional Iterative Health State Valuation Protocols

Cited by 12 publications

References 28 publications

Applicability of patient utilities as measures of overall quality of life in rheumatoid arthritis clinical trials

Applicability of patient utilities as measures of overall quality of life in rheumatoid arthritis clinical trials

New Findings from the TTO for Income Approach to Elicit Willingness to Pay for a QALY

Sequence effects in time trade‐off valuation of hypothetical health states

Contact Info

Product

Resources

About