A note on the effect of trifluoroacetate on the growth of rat liver

Blake, David A.; Barry, J; Cascorbi, Helmut F.

doi:10.1007/bf00997081

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The unreactive nature of TFA in the environment appears to translate into an inertness in organisms, thereby limiting its toxic effects [63]. TFA has been detected in a wide range of organisms [59,61,65,[70][71][72][73][74], but a primary concern relates to its potential toxicity in humans and other mammals. A full review of the question of mammalian toxicity can be found in Dekant et al [74], but can be summarized with the following: at the time of writing, the potential of TFA to induce toxicity in living organisms is considered to be very low.…”

Section: Toxicitymentioning

confidence: 99%

Trifluoroacetic Acid: Toxicity, Sources, Sinks and Future Prospects

Garavagno,

Holland,

Khan

et al. 2024

Sustainability

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Trifluoroacetic acid (TFA) is a known and persistent pollutant in the environment. Although several direct anthropogenic sources exist, production from the atmospheric degradation of fluorocarbons such as some hydrofluorocarbons (HFCs) has been a known source for some time. The current transition from HFCs to HFOs (hydrofluoroolefins) is beneficial from a global warming viewpoint because HFOs are much shorter-lived and pose a much smaller threat in terms of warming, but the fraction of HFOs converted into TFA is higher than seen for the corresponding HFCs and the region in which TFA is produced is close to the source. Therefore, it is timely to review the role of TFA in the Earth’s environment. This review considers its toxicity, sources and removal processes, measurement in a variety of environments, and future prospects. New global model integrations are used to quantify the impacts of uncertainties on TFA levels using the Henry’s Law constant for TFA and the range of gas-phase kinetic parameters chosen for the reaction of OH radicals with a representative HFO (HFO-1234yf). Model runs suggest that TFA surface concentrations vary by up to 10% based on Henry’s Law data but could be up to 25% smaller than previously modelled values suggest depending on the kinetic analysis adopted. Therefore, future estimates of TFA surface concentrations based on HFO removal require updating and the kinetic analysis of TFA production warrants further investigation. The toxicity of TFA appears to be low, but further studies of a much wider range of animal and plant types are required.

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